Strain Data Sheet
RBRC12542
Strain Information | |
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| Image | |
| BRC No. | RBRC12542 |
| Type | CRISPR/Cas9 (Transgene) |
| Species | Mus musculus |
| Strain name | C57BL/6J-Crhbp<em1(cre)Sleep> |
| Former Common name | Crhbp-2A-Cre |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Mitsuaki Kashiwagi, Goichi Beck, Mika Kanuka, Yoshifumi Arai, Kaeko Tanaka, Chika Tatsuzawa, Yumiko Koga, Yuki C Saito, Marina Takagi, Yo Oishi, Masanori Sakaguchi, Kousuke Baba, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masashi Yanagisawa, Shigeo Murayama, Takeshi Sakurai, Kazuya Sakai, Yoshimi Nakagawa, Masahiko Watanabe, Hideki Mochizuki, Yu Hayashi Cell, 187(22):6272-6289.e21 (2024). 39303715 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Crhbp MGI:88497 | corticotropin releasing hormone binding protein | 13 | Crhbp | ||||
| HBB | Rabbit β-globin poly(A) signal | 13 | HBB | ||||
| P2A | porcine teschovirus-1 2A peptide | 13 | P2A | ||||
| cre | Phage P1 Cre recombinase | 13 | cre | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | porcine teschovirus-1 P2A, phage P1 Cre, rabbit β-globin polyA, mouse Crhbp genomic DNA |
| Research application | Cre/loxP system Cre driver |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 187(22):6272-6289.e21 (2024). |
| Depositor | Yu Hayashi (University of Tsukuba) |
| Strain Status |  Live mice |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |