Strain Data Sheet

RBRC12177

Strain Information

Image
BRC No.RBRC12177
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6-Mapt<em1Maho>
Former Common nameTau 3R/3R-13
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms.
Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegawa
Brain, 145(1):349-361 (2022). 34515757

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mapt
MGI:97180		microtubule-associated protein tau11Mapt<em1Maho> endonuclease mediated mutation 1, Masato Hasegawa
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAStreptococcus pyogenes Cas9, gRNA, Mouse a part of Mapt gene
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Brain, 145(1):349-361 (2022). ・For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a
    prior written consent from the DEPOSITOR.
    ・The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMasato Hosokawa (Tokyo Metropolitan Institute of Medical Science)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data