Strain Data Sheet

RBRC11808

Strain Information

Image
BRC No.RBRC11808
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-hAPP770)Skita Tg(Tek-cre)1Ywa
Former Common nameEC-APP770+
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.
Kisanuki Y Y, Hammer R E, Miyazaki J, Williams S C, Richardson J A, Yanagisawa M
Dev. Biol., 230(2):230-42 (2001). 11161575

Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke.
David Sacks, Blaise Baxter, Bruce C V Campbell, Jeffrey S Carpenter, Christophe Cognard, Diederik Dippel, Muneer Eesa, Urs Fischer, Klaus Hausegger, Joshua A Hirsch, Muhammad Shazam Hussain, Olav Jansen, Mahesh V Jayaraman, Alexander A Khalessi, Bryan W Kluck, Sean Lavine, Philip M Meyers, Stephen Ramee, Daniel A Rüfenacht, Clemens M Schirmer, Dierk Vorwerk
Int. J. Stroke., 13(6):612-632 (2018). 29786478

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.
Yuriko Tachida, Saori Miura, Yui Muto, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi Saido, Shinobu Kitazume
J. Biol. Chem., 298(6):101880 (2022). 35367207

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
APP770amyloid-β precursor protein (human)UNAPP770CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
crePhage P1 Cre recombinaseUNcremouse Tek promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNACMV IE enhancer, ニワトリ beta-actin promoter, マウス Tie2 プロモーター, ウサギbeta-globin poly A, P1 ファージ loxP配列、Cre recombinase, ヒト Amyloid beta precursor protein 770NL, 大腸菌 ネオマイシン耐性遺伝子
Research applicationMetabolism Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 298(6):101880 (2022). Dev. Biol., 230(2):230-42 (2001).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE. For-profit organizations must contact the DEPOSITOR (shinobuk@fmu.ac.jp) for a licensing contract. If any invention is conceived and reduced to practice by RECIPIENT in the performance of the Research Plan involving the BIOLOGICAL RESOURCE during the term of this MTA, RECIPIENT agrees to promptly inform the invention to DEPOSITOR and the parties will consult each other to determine inventorship and ownership of the invention based on the respective parties contribution to the invention, before filing an application for a patent. In the case of a jointly owned application, the parties will separately enter into a joint application agreement including the sharing of ownership, patent costs and licensing income, as well as the responsible party for the application procedures etc.
DepositorShinobu Kitazume (RIKEN BSI)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. CAGGS MTA (English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data