Strain Information | |
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Image | |
BRC No. | RBRC11808 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6-Tg(CAG-hAPP770)Skita Tg(Tek-cre)1Ywa |
Former Common name | EC-APP770+ |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Kisanuki Y Y, Hammer R E, Miyazaki J, Williams S C, Richardson J A, Yanagisawa M Dev. Biol., 230(2):230-42 (2001). 11161575Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke. David Sacks, Blaise Baxter, Bruce C V Campbell, Jeffrey S Carpenter, Christophe Cognard, Diederik Dippel, Muneer Eesa, Urs Fischer, Klaus Hausegger, Joshua A Hirsch, Muhammad Shazam Hussain, Olav Jansen, Mahesh V Jayaraman, Alexander A Khalessi, Bryan W Kluck, Sean Lavine, Philip M Meyers, Stephen Ramee, Daniel A Rüfenacht, Clemens M Schirmer, Dierk Vorwerk Int. J. Stroke., 13(6):612-632 (2018). 29786478Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice. Yuriko Tachida, Saori Miura, Yui Muto, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi Saido, Shinobu Kitazume J. Biol. Chem., 298(6):101880 (2022). 35367207 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
APP770 | amyloid-β precursor protein (human) | UN | APP770 | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA) | |||
cre | Phage P1 Cre recombinase | UN | cre | mouse Tek promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | CMV IE enhancer, ニワトリ beta-actin promoter, マウス Tie2 プロモーター, ウサギbeta-globin poly A, P1 ファージ loxP配列、Cre recombinase, ヒト Amyloid beta precursor protein 770NL, 大腸菌 ネオマイシン耐性遺伝子 |
Research application | Metabolism Research Mouse Models for Human Disease |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 298(6):101880 (2022). Dev. Biol., 230(2):230-42 (2001).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE. For-profit organizations must contact the DEPOSITOR (shinobuk@fmu.ac.jp) for a licensing contract. If any invention is conceived and reduced to practice by RECIPIENT in the performance of the Research Plan involving the BIOLOGICAL RESOURCE during the term of this MTA, RECIPIENT agrees to promptly inform the invention to DEPOSITOR and the parties will consult each other to determine inventorship and ownership of the invention based on the respective parties contribution to the invention, before filing an application for a patent. In the case of a jointly owned application, the parties will separately enter into a joint application agreement including the sharing of ownership, patent costs and licensing income, as well as the responsible party for the application procedures etc. |
Depositor | Shinobu Kitazume (RIKEN BSI) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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