Strain Data Sheet

RBRC11633

Strain Information

Image
BRC No.RBRC11633
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameC57BL/6J-Del(6Tas2r143-Tas2r126)1Osb
Former Common nameTas2r143, Tas2r135, Tas2r126<-35404/wt>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Masahito Ikawa, Research Institute for Microbial Diseases, Osaka University in 2022. Fertilized eggs derived from C57BL/6J were used. C57BL/6J genetic background.
Strain descriptionDeletion mutant of 35,404 bp on chromosome 6 covering Tas2r143, Tas2r135 and Tas2r126.
Colony maintenance
References
Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.
Daichi Kobayashi, Tomoya Watarai, Madoka Ozawa, Yasuhiro Kanda, Fumihiro Saika, Norikazu Kiguchi, Arata Takeuchi, Masahito Ikawa, Shinsuke Matsuzaki, Tomoya Katakai
Front. Immunol., 13:973880 (2022). 36059440

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tas2r126
MGI:2681273		taste receptor, type 2, member 1266Tas2r126
Tas2r143
MGI:2681310		taste receptor, type 2, member 1436Tas2r143

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAStreptococcus pyogenes crRNA, tracrRNA, Mouse a part of Tas2r143 gene, Mouse a part of Tas2r126 gene
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Front. Immunol., 18 August Sec. Molecular Innate Immunity (2022) https://doi.org/10.3389/fimmu.2022.973880RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.
DepositorMasahito Ikawa (Osaka University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Co-creation Bureau, Osaka University HP

BRC mice in Publications

No Data