Strain Information | |
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Image | |
BRC No. | RBRC11565 |
Type | CRISPR/Cas9 (Transgene) |
Species | Mus musculus |
Strain name | C.Cg-Ace2<em1(ACE2)Okt> |
Former Common name | hACE2KI_NCGM |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Tadashi Oakmura, National Center for Global Health and Medicine, NCGM in 2021. This strain was generated using fertilized eggs derived from Slc:BDF1 x C57BL/6JJcl. Mice were backcrossed to BALB/c for 8 generations. |
Strain description | Knockin mice of human ACE2 at the Ace2 locus. |
Colony maintenance | |
References | Nat. Commun., 14(1):1076 (2023). 36841831 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
ACE2 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (human) | X | ACE2 | ||||
Ace2 | angiotensin converting enzyme 2 | X | Ace2 | endonuclease-mediated mutation 1, Tadashi Okamura | |||
HBB2 | rabbit beta-globin polyA signal | X | HBB2 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human ACE2 cDNA, rabbit beta-globin poly(A) signal sequence, mouse Ace2 genomic DNA |
Research application | Immunology and Inflammation Research Virology Research covid19_infection |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat Commun., 14(1):1076 (2023). doi: 10.1038/s41467-023-36729-0. |
Depositor | Tadashi Okamura (National Center for Global Health and Medicine) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |