Strain Data Sheet

RBRC11177

Strain Information

Image
BRC No.RBRC11177
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Mecom<tm1Mmor>/Kmori
Former Common nameEvi1, MECOM, PRDM3
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentDeposited by Kazuhiro Morishita, Miyazaki University in 2020.
Strain descriptionMecom mutant mice.
Colony maintenance
References
The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.
Hoyt P R, Bartholomew C, Davis A J, Yutzey K, Gamer L W, Potter S S, Ihle J N, Mucenski M L
Mech Dev., 65(1-2):55-70 (1997). 9256345

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression.
Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, Mucenski M L, Suda T, Morishita K
EMBO J., 24(11):1976-87 (2005). 15889140

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mecom
MGI:95457		MDS1 and EVI1 complex locus3Mecom<tm1Mmor>
MGI:1857461		targeted mutation 1, Michael L Mucenski
  • radioulnar synostosis with amegakaryocytic thrombocytopenia 2(MedGEN)
    • neo neomycin resistance gene (E. coli)3 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E.coli neomycin resistance gene, mouse Mecom genomic DNA
    Research applicationHematological Research
    Mouse Models for Human Disease
    Specific Term and ConditionsFor use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorKazuhiro Morishita (University of Miyazaki)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data