Strain Data Sheet

RBRC10878

Strain Information

Image
BRC No.RBRC10878
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameD2.B6-Tardbp<Rgsc02223>
Former Common nameM102223, LCDmut (M323K)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited from Dr. Abraham Acevedo-Arozena at MRC Mammalian Genetics Unit, Harwell, UK.
Strain descriptionMutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis. Gene: Tardbp, Substitution: T->A. DBA/2 congenic strain.
Colony maintenance
References
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas J M, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella A E, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chio A, Isaacs A M, Fawzi N L, Wang E, Housman D E, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher E M, Acevedo-Arozena A
EMBO J., 37(11):e98684 (2018). 29764981

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tardbp
MGI:2387629		TAR DNA binding protein4Tardbp<Rgsc02223> RIKEN Genomic Sciences Center (GSC), 2223
  • amyotrophic lateral sclerosis type 10(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 37(11):e98684 (2018).
    DepositorTom Cunningham (Medical Research Council)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data