Strain Data Sheet
RBRC10877
Strain Information | |
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| Image | |
| BRC No. | RBRC10877 |
| Type | Chemically-induced Mutation |
| Species | Mus musculus |
| Strain name | B6(D2)-Tardbp<Rgsc02223> |
| Former Common name | M102223, LCDmut (M323K) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited from Dr. Abraham Acevedo-Arozena at MRC Mammalian Genetics Unit, Harwell, UK. |
| Strain description | Mutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis. Gene: Tardbp, Substitution: T->A. C57BL/6J congenic strain. |
| Colony maintenance | |
| References | Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas J M, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella A E, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chio A, Isaacs A M, Fawzi N L, Wang E, Housman D E, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher E M, Acevedo-Arozena A EMBO J., 37(11):e98684 (2018). 29764981 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Tardbp MGI:2387629 | TAR DNA binding protein | 4 | Tardbp<Rgsc02223> | RIKEN Genomic Sciences Center (GSC), 2223 | |||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | |
| Research application | |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 37(11):e98684 (2018). |
| Depositor | Tom Cunningham (Medical Research Council) |
| Strain Status |  Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |