Strain Data Sheet
RBRC10875
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC10875 |
| Type | Chemically-induced Mutation |
| Species | Mus musculus |
| Strain name | B6(D2)-Tardbp<Rgsc02268> |
| Former Common name | M102268, RRM2Mut (F210I) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited from Dr. Abraham Acevedo-Arozena at MRC Mammalian Genetics Unit, Harwell, UK. |
| Strain description | Mutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis.Gene: Tardbp, Substitution: T->A. C57BL/6J congenic strain. |
| Colony maintenance | |
| References | Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. Pietro Fratta, Prasanth Sivakumar, Jack Humphrey, Kitty Lo, Thomas Ricketts, Hugo Oliveira, Jose M Brito-Armas, Bernadett Kalmar, Agnieszka Ule, Yichao Yu, Nicol Birsa, Cristian Bodo, Toby Collins, Alexander E Conicella, Alan Mejia Maza, Alessandro Marrero-Gagliardi, Michelle Stewart, Joffrey Mianne, Silvia Corrochano, Warren Emmett, Gemma Codner, Michael Groves, Ryutaro Fukumura, Yoichi Gondo, Mark Lythgoe, Erwin Pauws, Emma Peskett, Philip Stanier, Lydia Teboul, Martina Hallegger, Andrea Calvo, Adriano Chiò, Adrian M Isaacs, Nicolas L Fawzi, Eric Wang, David E Housman, Francisco Baralle, Linda Greensmith, Emanuele Buratti, Vincent Plagnol, Elizabeth Mc Fisher, Abraham Acevedo-Arozena EMBO J., 37(11):e98684 (2018). 29764981 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Tardbp MGI:2387629 | TAR DNA binding protein | 4 | Tardbp<Rgsc02268> | RIKEN Genomic Sciences Center (GSC), 2268 | |||
Phenotype | |
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| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | |
| Research application | |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 37(11):e98684 (2018). |
| Depositor | Tom Cunningham (Medical Research Council) |
| Strain Status |  Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |