Strain Information | |
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Image | |
BRC No. | RBRC10756 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Mab21l1<tm1Nao> |
Former Common name | C57BL/6(Mab21l1tm1Nao), Mab21l1tm1Nao |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | |
Strain development | 奈良先端科学技術大学院大学・高橋直樹 (2003年)R1 ES 細胞を用いて作出。C57BL/6コンジェニック系統。Mab21l1tm1Nao heterozygouteをC57BL/6J Jclに8世代戻し交配を行う。その後、兄妹交配にて維持。ホモ型不妊abnormal male preputial gland morphology abnormal eye morphology abnormal skull development |
Strain description | This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development.Mutation details: The entire gene coding region was replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutants was confirmed by whole mount in situ hybridization analysis of E10.5 homozygous mutant embryos. |
Colony maintenance | |
References | Development, 130(9), 1759-1770 (2003). 12642482 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)3herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA3 |
Ordering Information | |
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供与核酸 | 大腸菌(クラス1) Neomycin resistant gene, 単純ヘルペスウイルス1型(クラス2) Thymidine Kinase promoter, シミアンウイルス40(SV40)(クラス2) PolyA signal |
Research application | |
提供条件 | 条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。 |
Depositor | 高橋 直樹(国立大学法人東京大学) |
Strain Status | 凍結精子 |
Strain Availability | 凍結精子より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |