Strain Data Sheet



BRC No.RBRC10430
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6J(D2)-Jak1<spade>/RgscHko
Former Common nameSpade-B6J(N10)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Strain developmentDeveloped by Hisahiro Yoshida RIKEN, in 2003. This strain was backcrossed to C57BL/6J for 10 generations.
Strain descriptionENU mutant mice for the Jak1 gene. A point mutation in the Jak1 gene, which increase a kinase activity of Jak1. Mutants develop dermatitis around 8 to 10 weeks of their age.
Colony maintenance
ReferencesJ. Clin. Invest., 126(6):2064-2076 (2016). 27111231

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Jak1Janus kinase 14Jak1<spade>


Donor DNA
Research applicationDermatology Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHaruhiko Koseki (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data