Strain Data Sheet

RBRC10429

Information1

Image
BRC No.RBRC10429
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6N(D2)-Jak1<spade>/RgscHko
Former Common nameSpade-B6N(N7)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hisahiro Yoshida RIKEN, in 2003. This strain was backcrossed to C57BL/6N for 7 generations.
Strain descriptionENU mutant mice for the Jak1 gene. A point mutation in the Jak1 gene, which increase a kinase activity of Jak1. Mutants develop dermatitis around 8 to 10 weeks of their age.
Colony maintenance
ReferencesJ. Clin. Invest., 126(6):2064-2076 (2016). 27111231

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Jak1Janus kinase 14Jak1<spade>

Information2

Donor DNA
Research applicationDermatology Research
covid19_onset
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHaruhiko Koseki (RIKEN)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data