Strain Data Sheet


Strain Information

BRC No.RBRC10057
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Eif2b5<toy>
Former Common nameB6Toy, Eif2b5<I98M>
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Mika Tsujita, Brain Research Institute, Niigata University in 2008. Point mutation was identified in 2012. C57BL/6 genetic background.
Strain descriptionSpontaneous mutants exhibiting phenotypes similar to the Vanishing white matter disease. A point mutation (I98M) in the Eif2b5 (eukaryotic translation initiation factor 2B, subunit 5 epsilon) gene. Homozygous mutants show decreased body weight (starting around 3 weeks old) and impaired motor coordination. Homozygous mice are infertile, but sperms can be used for in vitro fertilization. WT: GCTGCTCAGATCAAAGAACACTTAToy: GCTGCTCAGATGAAAGAACACTTA
Colony maintenance
ReferencesJ. Neurochem., 154(1):25-40 (2020). 31587290

Health Report

Examination Date / Room / Rack2023/11/20Room:4-ARack:D


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Eif2b5eukaryotic translation initiation factor 2B, subunit 5 epsilon16Eif2b5<toy>eukaryotic translation initiation factor 2B, subunit 5 epsilon; toyEif2b5^I98M

Ordering Information

Donor DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurochem., 154(1):25-40 (2020).
DepositorMika Terumitsu-Tsujita (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-
Mouse of the Month Oct 2021

BRC mice in Publications

No Data