Strain Information | |
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Image | |
BRC No. | RBRC09998 |
Type | Spontaneous Mutation Congenic |
Species | Mus musculus |
Strain name | B6J.ICR-Tpo<R479C>/Ham |
Former Common name | B6.ICR-Tpo |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Shuji Takabayashi, Hamamatsu University School of Medicine in 2006. A spontaneous mutation found in Jcl:ICR was backcrossed to C57BL/6J for 12 generations, and then mice were maintained by sister-brother mating for 30 generations. |
Strain description | Spontaneous mutant harboring a missense mutation from C to T at position 1608 of the thyroid peroxidase (Tpo) gene. This mutation results in amino acid exchange from Arg to Cys at 479th amino acid. |
Colony maintenance | |
References | A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse. Takabayashi S, Umeki K, Yamamoto E, Suzuki T, Okayama A, Katoh H Mol. Endocrinol., 20, 2584-2590 (2006). 16762971 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Tpo | thyroid peroxidase | 12 | Tpo | thyroid peroxidase; R479C |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 9 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Endocrine Deficiency Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Endocrinol., 20, 2584-2590 (2006).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Shuji Takabayashi (Hamamatsu University School of Medicine) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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