Strain Information | |
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Image | |
BRC No. | RBRC09686 |
Type | Chemically-induced Mutation Congenic |
Species | Mus musculus |
Strain name | C3.B6-Tdrd12<repro23> |
Former Common name | Repro23 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C3H/HeJJcl |
Appearance | |
Strain development | Developed by the NIH-supported Reproductive Genomics program at JAX. Deposited by Tetsuo Kunieda, Okayama University in 2016. C3H congenic line. |
Strain description | An ENU-induced mutant line harboring a nonsense mutation of the 8th exon of the mouse Tdrd12 (Tudor domain containing 12) gene. Male homozygotes exhibit infertility. Female homozygotes are fertile. |
Colony maintenance | |
References | Characterization and linkage mapping of an ENU-induced mutant mouse with defective spermatogenesis. Asano Y, Akiyama K, Tsuji T, Takahashi S, Noguchi J, Kunieda T Exp. Anim., 58. 525-532, (2009). 19897936Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Pandey R R, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai R S Proc. Natl. Acad. Sci. USA, 110, 16492-16497 (2013). 24067652 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Tdrd12 | tudor domain containing 12 | 7 | Tdrd12 | reproductive mutant 23, JAX Reproductive Mutagenesis Program |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 19 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Tetsuo Kunieda (Okayama University) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |