Strain Data Sheet

RBRC09438

Strain Information

Image
BRC No.RBRC09438
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameSTOCK-Cebpb<tm1Kish>/47 (B6;D2;129P2)
Former Common nameNF-IL6 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T
Cell, 80, 353-361 (1995). 7530603

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cebpb
MGI:88373		CCAAT/enhancer binding protein beta2Cebpb targeted mutation 1, Tadamitsu Kishimoto
neo neomycin resistance gene (E. coli)2 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal brown adipose tissue morphology(MP:0002971)

  • abnormal cell differentiation(MP:0005076)

  • abnormal clavicle morphology(MP:0005298)

  • abnormal macrophage physiology(MP:0002451)

  • abnormal skeletal muscle mass(MP:0004817)
    • more 9 phenotypes
  • abnormal thoracic cage morphology(MP:0004624)

  • abnormal zygomatic arch morphology(MP:0004469)

  • female infertility(MP:0001926)

  • impaired macrophage phagocytosis(MP:0001798)

  • increased interleukin-12 secretion(MP:0008663)

  • increased susceptibility to bacterial infection(MP:0002412)

  • neonatal lethality, incomplete penetrance(MP:0011088)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • postnatal lethality, incomplete penetrance(MP:0011086)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse Cebpb genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University.
    DepositorShigemi Kinoshita (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Co-creation Bureau, Osaka University HP

    BRC mice in Publications

    No Data