Strain Information | |
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Image | |
BRC No. | RBRC09393 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6-Kcnj11<tm2Sse> |
Former Common name | Kir6.2-flox |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Susumu Seino, Kobe University Graduate School of Medicine. ES cells derived from C57BL/6 were used. C57BL/6 genetic background. |
Strain description | |
Colony maintenance | |
References | Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes. Okechi S Oduori, Naoya Murao, Kenju Shimomura, Harumi Takahashi, Quan Zhang, Haiqiang Dou, Shihomi Sakai, Kohtaro Minami, Belen Chanclon, Claudia Guida, Lakshmi Kothegala, Johan Tolö, Yuko Maejima, Norihide Yokoi, Yasuhiro Minami, Takashi Miki, Patrik Rorsman, Susumu Seino J. Clin. Invest., 130(12):6639-6655 (2020). 33196462 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Frt | yeast FRT (flippase recombination target) site | 7 | Frt | ||||
Frt | yeast FRT (flippase recombination target) site | 7 | Frt | ||||
GH | Growth hormone polyA (Bovine) | 7 | GH | ||||
Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 7 | Kcnj11 | targeted mutation 2, Susumu Seino | |||
loxP | phage P1 loxP | 7 | loxP | ||||
loxP | phage P1 loxP | 7 | loxP | ||||
neo | neomycin resistance gene (E. coli) | 7 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Phage P1 loxP sites, Yeast FRT (flippase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, Bovine Growth hormone poly A signal, mouse Kcnj11 genomic DNA |
Research application | Cre/loxP system Endocrine Deficiency Research FLP/frt system Neurobiology Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Susumu Seino (Kobe University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |