Strain Data Sheet

RBRC09392

update : 2026-03-19

Strain Information
Image
BRC No.	RBRC09392
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6;129-Rims2<tm1Sse>
Former Common name	Rim2a-KO; Rim2 alpha-
H-2 Haplotype
ES Cell line	Not specified (ES cell)
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References	Rim2alpha determines docking and priming states in insulin granule exocytosis. Takao Yasuda, Tadao Shibasaki, Kohtaro Minami, Harumi Takahashi, Akira Mizoguchi, Yoshitsugu Uriu, Tomohiro Numata, Yasuo Mori, Jun-Ichi Miyazaki, Takashi Miki, Susumu Seino Cell Metab., 12(2):117-129 (2010). 20674857

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Rims2 MGI:2152972	regulating synaptic membrane exocytosis 2	15	Rims2<tm1Sse> MGI:4838195	targeted mutation 1, Susumu Seino			cone-rod synaptic disorder syndrome, congenital nonprogressive(MedGEN)
neo	neomycin resistance gene (E. coli)	15

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	abnormal pancreatic beta cell physiology (MP:0003562) decreased body size (MP:0001265) decreased circulating adrenaline level (MP:0005661) decreased circulating glucose level (MP:0005560) decreased circulating growth hormone level (MP:0005120) more 8 phenotypes decreased circulating insulin level (MP:0002727) decreased circulating insulin-like growth factor I level (MP:0004701) decreased insulin secretion (MP:0003059) impaired glucose tolerance (MP:0005293) increased circulating glucagon level (MP:0002712) increased circulating glucose level (MP:0005559) increased pancreatic alpha cell number (MP:0009176) pancreatic islet hyperplasia (MP:0005491)
Detailed phenotype data

Phenotype annotation from literatures by Mammalian phenotype ontology

abnormal pancreatic beta cell physiology (MP:0003562)

decreased body size (MP:0001265)

decreased circulating adrenaline level (MP:0005661)

decreased circulating glucose level (MP:0005560)

decreased circulating growth hormone level (MP:0005120)

more 8 phenotypes

decreased circulating insulin level (MP:0002727)

decreased circulating insulin-like growth factor I level (MP:0004701)

decreased insulin secretion (MP:0003059)

impaired glucose tolerance (MP:0005293)

increased circulating glucagon level (MP:0002712)

increased circulating glucose level (MP:0005559)

increased pancreatic alpha cell number (MP:0009176)

pancreatic islet hyperplasia (MP:0005491)

Detailed phenotype data

Ordering Information
Donor DNA	E. coli Neomycin resistance gene
Research application	Endocrine Deficiency Research
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Metab., 12(2):117-129 (2010). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Depositor	Susumu Seino (Kobe University)
Strain Status	Frozen embryos
Strain Availability	Recovery and QC required prior to distribution
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data