Strain Data Sheet

RBRC09392

Strain Information

Image
BRC No.RBRC09392
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Rims2<tm1Sse>
Former Common nameRim2a-KO; Rim2 alpha-
H-2 Haplotype
ES Cell lineNot specified (ES cell)
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Rim2alpha determines docking and priming states in insulin granule exocytosis.
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J, Miki T, Seino S
Cell Metab., 12(2):117-129 (2010). 20674857

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Rims2regulating synaptic membrane exocytosis 215Rims2targeted mutation 1, Susumu Seino
  • cone-rod synaptic disorder syndrome, congenital nonprogressive(MedGEN)
  • neoneomycin resistance gene (E. coli)15
  • cone-rod synaptic disorder syndrome, congenital nonprogressive(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal pancreatic beta cell physiology(MP:0003562)

  • decreased body size(MP:0001265)

  • decreased circulating adrenaline level(MP:0005661)

  • decreased circulating glucose level(MP:0005560)

  • decreased circulating growth hormone level(MP:0005120)
  • more 8 phenotypes
  • decreased circulating insulin level(MP:0002727)

  • decreased circulating insulin-like growth factor I level(MP:0004701)

  • decreased insulin secretion(MP:0003059)

  • impaired glucose tolerance(MP:0005293)

  • increased circulating glucagon level(MP:0002712)

  • increased circulating glucose level(MP:0005559)

  • increased pancreatic alpha cell number(MP:0009176)

  • pancreatic islet hyperplasia(MP:0005491)
  • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene
    Research applicationEndocrine Deficiency Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Metab., 12(2):117-129 (2010). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorSusumu Seino (Kobe University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data