Strain Data Sheet
RBRC06803
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC06803 |
| Type | Inbred |
| Species | Mus musculus |
| Strain name | STR/OrtCrlj |
| Former Common name | STR |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | NIH (1951), NIH to Institute of Stanmore (UK) in 1970, Institute of Stanmore to OLAC (UK) in 1982, OLAC to Imperial College of Science, Technology & Medicine (UK) in 1990, Imperial College of Science to Charles River Laboratories, Inc. (USA), and then to Charles River Laboratories, Japan in 2001. |
| Strain description | A model for spontaneous osteoarthritis. |
| Colony maintenance | Sibling x Sibling |
| References | Radiological scoring of osteoarthritis progression in STR/ORT mice. R G Evans, C Collins, P Miller, F M Ponsford, C J Elson Osteoairthritis and Cartilage, 2, 103-109 (1994). 11548226The STR/ort mouse and its use as a model of osteoarthritis. R M Mason, M G Chambers, J Flannelly, J D Gaffen, J Dudhia, M T Bayliss Osteoairthritis and Cartilage, 9, 85-91 (2001). 11237655CRJ Letters, 19, 1-10 (2009). |
Health Report | |
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| Examination Date / Room / Rack | 2025/11/10Room:3-ARack:KSentinel mouse program 2025/09/01Room:3-ARack:KSentinel mouse program 2025/06/16Room:3-ARack:KSentinel mouse program 2025/04/07Room:3-ARack:KSentinel mouse program 2025/01/07Room:3-ARack:KSentinel mouse program 2024/10/07Room:3-ARack:KSentinel mouse program 2024/07/08Room:3-ARack:KSentinel mouse program |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Jcdq1 MGI:5883580 | joint cartilage degeneration QTL 1 | 4 | Jcdq1 MGI:5883583 | ||||
| Jcdq2 MGI:5883581 | joint cartilage degeneration QTL 2 | 5 | Jcdq2 MGI:5883584 | ||||
Phenotype | |
|---|---|
| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | |
| Research application | Mouse Models for Human Disease |
| Specific Term and Conditions | If the user wished to transfer to the third party, has to obtain permission from the depositor in advance. |
| Depositor | Charles River Laboratories Japan, Inc. (CHARLES RIVER LABORATORIES JAPAN, INC.) |
| Strain Status |  Live mice Frozen embryos |
| Strain Availability | Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Chang Y, Jiang PH, Hsu YH, Lin YC, Hu CC, Li YZ, Ueng SW, Chen MF. Targeting EFEMP1 enhances chondrogenesis and inhibits hypertrophic differentiation in a spontaneous osteoarthritis mouse model. J Mol Med (Berl) 104(1) (2026) 41848842 |