Strain Data Sheet

RBRC06798

Strain Information

Image
BRC No.RBRC06798
TypeWild-derived Inbred and Spontaneous Mutation
SpeciesMus musculus molossinus
Strain nameMSM.MRL-Fas<lpr>
Former Common nameMSM-lpr
H-2 Haplotype
ES Cell line
Background strainMSM/Ms
Appearance
Strain development名古屋大学大学院医学系研究科・大野民生先生（2015）。MSM/Ms系統にMRL/MpJJmsSlc-lpr系統のlpr遺伝子座を戻し交配により導入（N10世代）。
Strain description日本産野生マウス由来MSM/Ms系統にMRL/MpJ-lpr系統由来のlpr遺伝子座領域を導入したコンジェニック系統であり、既存のlprコンジェニック系統(MRL-lpr、B6-lpr、C3H-lpr、NC-lpr)系統と比較することでlpr遺伝子の機能やその修飾遺伝子の解析を行うことができる。生後3ヶ月齢頃までは外見上はMSM/Msと同様であり、繁殖性も比較的良好である。その後、徐々にlpr遺伝子座の影響による病態を発症する。
Colony maintenanceHomozygote x Homozygote [or Crossing to MSM/Ms]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fas
MGI:95484		Fas cell surface death receptor19Fas<lpr>
MGI:1856334		lymphoproliferation
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • CNS inflammation (MP:0006082)

  • abnormal B cell activation (MP:0008217)

  • abnormal B cell morphology (MP:0004939)

  • abnormal B cell receptor editing (MP:0008766)

  • abnormal NK cell physiology (MP:0010766)
    • more 145 phenotypes
  • abnormal T cell morphology (MP:0008037)

  • abnormal T cell physiology (MP:0002444)

  • abnormal T cell proliferation (MP:0005094)

  • abnormal T-helper 2 physiology (MP:0005466)

  • abnormal airway responsiveness (MP:0002334)

  • abnormal cardiovascular system physiology (MP:0001544)

  • abnormal circulating protein level (MP:0005416)

  • abnormal conjunctival epithelium morphology (MP:0004481)

  • abnormal coronary artery morphology (MP:0004111)

  • abnormal cytotoxic T cell physiology (MP:0005078)

  • abnormal enzyme/coenzyme activity (MP:0005584)

  • abnormal gland morphology (MP:0002163)

  • abnormal glomerular capillary endothelium morphology (MP:0011453)

  • abnormal glomerular capillary morphology (MP:0011320)

  • abnormal hepatocyte morphology (MP:0000607)

  • abnormal immune system organ morphology (MP:0002722)

  • abnormal immune system physiology (MP:0001790)

  • abnormal immunoglobulin level (MP:0002490)

  • abnormal interleukin level (MP:0008751)

  • abnormal kidney morphology (MP:0002135)

  • abnormal kidney physiology (MP:0002136)

  • abnormal leukocyte adhesion (MP:0003628)

  • abnormal leukocyte morphology (MP:0008246)

  • abnormal liver physiology (MP:0000609)

  • abnormal lymph node cell ratio (MP:0008828)

  • abnormal lymph node morphology (MP:0002339)

  • abnormal marginal zone B cell morphology (MP:0008180)

  • abnormal myocardium layer morphology (MP:0005329)

  • abnormal renal glomerulus basement membrane morphology (MP:0011348)

  • abnormal renal glomerulus morphology (MP:0005325)

  • abnormal skin condition (MP:0001191)

  • abnormal spatial learning (MP:0001463)

  • abnormal splenic cell ratio (MP:0008826)

  • abnormal stria vascularis morphology (MP:0000048)

  • abnormal stria vascularis vasculature morphology (MP:0004368)

  • abnormal strial intermediate cell morphology (MP:0004367)

  • abnormal submandibular gland morphology (MP:0003793)

  • abnormal thymus medulla morphology (MP:0002375)

  • abnormal thyroid follicle morphology (MP:0004696)

  • abnormal thyroid gland morphology (MP:0000681)

  • abnormal type III hypersensitivity reaction (MP:0002533)

  • abnormal vagina weight (MP:0008978)

  • albuminuria (MP:0002871)

  • autoimmune response (MP:0001844)

  • blood vessel inflammation (MP:0001863)

  • brain inflammation (MP:0001847)

  • conjunctivitis (MP:0001852)

  • cortical renal glomerulopathies (MP:0000523)

  • decreased B cell apoptosis (MP:0008783)

  • decreased B cell number (MP:0005017)

  • decreased CD4-positive, alpha-beta T cell number (MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased IgG level (MP:0001805)

  • decreased activated T cell number (MP:0001830)

  • decreased apoptosis (MP:0006043)

  • decreased eosinophil cell number (MP:0005012)

  • decreased hepatocyte apoptosis (MP:0008891)

  • decreased immature B cell number (MP:0008215)

  • decreased interleukin-2 secretion (MP:0008688)

  • decreased macrophage apoptosis (MP:0011081)

  • decreased marginal zone B cell number (MP:0008182)

  • decreased mature B cell number (MP:0008211)

  • decreased neuron apoptosis (MP:0003204)

  • decreased spleen germinal center number (MP:0008482)

  • decreased susceptibility to autoimmune diabetes (MP:0004804)

  • decreased transitional stage B cell number (MP:0008190)

  • demyelination (MP:0000921)

  • dilated renal glomerular capsule (MP:0003670)

  • enlarged Peyer's patches (MP:0008136)

  • enlarged lymph nodes (MP:0000702)

  • enlarged spleen (MP:0000691)

  • enlarged thymus (MP:0000709)

  • epidermal necrosis (MP:0001220)

  • expanded mesangial matrix (MP:0011353)

  • focal hepatic necrosis (MP:0001656)

  • glomerular crescent (MP:0011506)

  • glomerulonephritis (MP:0002743)

  • impaired coordination (MP:0001405)

  • impaired leukocyte tethering or rolling (MP:0020332)

  • increased IgA level (MP:0002495)

  • increased IgG level (MP:0002493)

  • increased IgG1 level (MP:0008499)

  • increased IgG2a level (MP:0008500)

  • increased IgG2b level (MP:0008501)

  • increased IgG3 level (MP:0008502)

  • increased IgM level (MP:0002494)

  • increased anti-double stranded DNA antibody level (MP:0004762)

  • increased anti-erythrocyte antigen antibody level (MP:0004797)

  • increased anti-histone antibody level (MP:0004796)

  • increased anti-nuclear antigen antibody level (MP:0004794)

  • increased anti-single stranded DNA antibody level (MP:0004771)

  • increased apoptosis (MP:0006042)

  • increased autoantibody level (MP:0003725)

  • increased blood urea nitrogen level (MP:0005565)

  • increased body weight (MP:0001260)

  • increased circulating serum albumin level (MP:0002965)

  • increased circulating total protein level (MP:0005568)

  • increased double-negative T cell number (MP:0005090)

  • increased follicular B cell number (MP:0008173)

  • increased gamma-delta T cell number (MP:0008346)

  • increased immature B cell number (MP:0008214)

  • increased immunoglobulin level (MP:0002461)

  • increased kidney cell proliferation (MP:0011440)

  • increased marginal zone B cell number (MP:0008181)

  • increased mesangial cell number (MP:0011427)

  • increased neutrophil cell number (MP:0000219)

  • increased or absent threshold for auditory brainstem response (MP:0011967)

  • increased plasma cell number (MP:0008097)

  • increased renal glomerulus apoptosis (MP:0011369)

  • increased renal glomerulus basement membrane thickness (MP:0011409)

  • increased spleen weight (MP:0004952)

  • increased splenocyte number (MP:0009338)

  • increased susceptibility to Picornaviridae infection (MP:0020937)

  • increased susceptibility to autoimmune disorder (MP:0005350)

  • increased susceptibility to bacterial infection (MP:0002412)

  • increased susceptibility to induced morbidity/mortality (MP:0009763)

  • increased susceptibility to systemic lupus erythematosus (MP:0004801)

  • increased susceptibility to type III hypersensitivity reaction (MP:0005615)

  • increased susceptibility to viral infection (MP:0002418)

  • increased thymus weight (MP:0004955)

  • increased transitional stage B cell number (MP:0008189)

  • increased tumor incidence (MP:0002020)

  • increased urine protein level (MP:0002962)

  • joint swelling (MP:0002936)

  • kidney failure (MP:0003606)

  • kidney inflammation (MP:0001859)

  • lacrimal gland atrophy (MP:0013455)

  • lacrimal gland inflammation (MP:0008880)

  • lymph node hemorrhage (MP:0031051)

  • lymph node hyperplasia (MP:0008102)

  • lymph node necrosis (MP:0031052)

  • podocyte foot process effacement (MP:0008140)

  • premature death (MP:0002083)

  • renal cast (MP:0011402)

  • renal glomerular immunoglobulin deposits (MP:0020519)

  • renal glomerular protein deposits (MP:0020518)

  • renal glomerulus hypertrophy (MP:0011294)

  • ruffled hair (MP:0000420)

  • salivary gland inflammation (MP:0001870)

  • skin lesions (MP:0001212)

  • submandibular gland inflammation (MP:0008879)

  • thymus atrophy (MP:0003644)

  • thymus cortex atrophy (MP:0013585)

  • thyroid gland inflammation (MP:0003504)

  • vascular inflammation (MP:0001864)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationImmunology and Inflammation Research
    提供条件利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。研究成果の公表にあたって謝辞の表明を必要とする。営利目的利用の希望については、希望者は予め名大知財・技術移転グループに連絡し、承諾を得る。共同研究。
    Depositor大野　民生（国立大学法人名古屋大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data