Strain Data Sheet

RBRC06410

update : 2024-04-19

Strain Information
Image
BRC No.	RBRC06410
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6.Cg-Nfkbiz<tm1.1Muta>
Former Common name	IκB-ζ flox/flox, B6-Nfkbiz floxed
H-2 Haplotype
ES Cell line	Bruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development	東北大学大学院生命科学研究科・牟田達史先生。Bruce 4 ES細胞を用いて作出。Frt-neoカセットはCAG-FLPe（B6）マウスとの交配より除去済。
Strain description	IκB-ζ (Nfkbiz) 遺伝子のfloxedマウス。エクソン5から7がloxPで挟まれている。
Colony maintenance	Homozygote x Homozygote [or Crossing to C57BL/6JJmsSlc]
References	Immunity, 38, 450-460 (2013). 23453632

Health Report
Examination Date / Room / Rack	2024/01/09Room:3-BRack:L 2023/10/10Room:3-BRack:L 2023/07/10Room:3-BRack:L 2023/04/10Room:3-BRack:L 2023/03/24Room:3-BRack:L 2023/01/10Room:3-BRack:L 2022/10/11Room:3-BRack:L 2022/07/11Room:3-BRack:L

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta16Nfkbiz<tm1.1Muta>targeted mutation 1.1, Tatsushi Muta Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site16Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP16loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP16loxP

Gene

Gene info

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta16Nfkbiz<tm1.1Muta>targeted mutation 1.1, Tatsushi Muta

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Frtyeast FRT (flippase recombination target) site16Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

loxPphage P1 loxP16loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

loxPphage P1 loxP16loxP

Ordering Information
供与核酸	P1 phage loxP sites, yeast FRT (flippase recombination target) site, mouse Nfkbiz genomic DNA
Research application	Cre/loxP system FLP/frt system
提供条件	条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
Depositor	丸山　貴司（国立大学法人岐阜大学）
Strain Status	生体凍結胚凍結精子
Strain Availability	凍結精子を1ヶ月以内に提供可能凍結胚を1ヶ月以内に提供可能生体マウスを3~6ヶ月以内に提供可能
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Genotyping protocol -PCR- Mouse of the Month Apr 2017

BRC mice in Publications

Taylor TC, Coleman BM, Arunkumar SP, Dey I, Dillon JT, Ponde NO, Poholek AC, Schwartz DM, McGeachy MJ, Conti HR, Gaffen SL. IκBζ is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe (2023) 37725983 Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature 577(7789) 260-265(2020) 31853061 Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol 7(76) eabm9811(2022) 36306369 Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal 15(758) eabl5304(2022) 36318619

BRC mice in Publications

Taylor TC, Coleman BM, Arunkumar SP, Dey I, Dillon JT, Ponde NO, Poholek AC, Schwartz DM, McGeachy MJ, Conti HR, Gaffen SL.
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.
Cell Host Microbe (2023) 37725983

Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S.
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
Nature 577(7789) 260-265(2020) 31853061

Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S.
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis.
Sci Immunol 7(76) eabm9811(2022) 36306369

Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R.
Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes.
Sci Signal 15(758) eabl5304(2022) 36318619

Strain Information

Health Report

Gene

Ordering Information

BRC mice in Publications