Strain Data Sheet

RBRC06395

Strain Information

Image
BRC No.RBRC06395
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Fbxw7<tm2.1Kei>
Former Common nameFbxw7b KO, B6-Fbxw7b KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N6 generations).
Strain descriptionFbxw7 bete isoform knockout mice (delta E1 beta type).
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
References
Fbxw7beta resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama K I
Cancer Sci., 102, 749-755 (2011). 21205095

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fbxw7
MGI:1354695		F-box and WD-40 domain protein 73Fbxw7<tm2.1Kei> targeted mutation 2.1, Kei-ichi Nakayama
loxP phage P1 loxP3loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage P1 LoxP sequence
    Research applicationCell Biology Research
    Cre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorKeiichi Nakayama (Kyushu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data