Strain Data Sheet

Kim Y, Lee G, An S, Park H, Kim H, Kim J, Kang S, Kim S, Kwon D, Park J, Hwang Y, Kim S, Yuan X, Jeong J, Lee H, Kim HK, Kim J.
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7.
Adv Sci (Weinh) e76658(2026) 42467931

Araki K, Yamauchi K, Ito S, Koike M, Hioki H.
The difference in immunohistochemical reactivity of monoclonal antibodies against amino-terminal residues of amyloid-β peptide.
Anat Sci Int (2026) 41505017

Kim J, Hwang Y, Kim S, Kwon D, Park J, Cho B, An S, Kang S, Kim Y, Kim S, Lengner CJ, Kim S, Kwon Y, Sung JS, Kim J.
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression.
Cell (2026) 41985457

Ohi Y, Hada K, Murata Y, Kodama D, Wakiya Y.
Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice.
J Pharmacol Sci 160(1) 37-40(2026) 41390193

Li C, Chia XW, Xu G, Ang LF, Makino H.
Vulnerability of short-term memory in a mouse model of Alzheimer's disease.
Nat Commun (2026) 41714332

Nakagawa T, Xie JL, Park K, Cao K, Savadkohighodjanaki M, Zhang YJ, Jun H, Ichii A, Lee JY, Soma S, Medhat YK, Saido TC, Igarashi KM.
Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer's disease.
Nat Neurosci 29(6) 1386-1396(2026) 42026254

Takeda A, Takeuchi T, Minakawa EN, Tanaka N, Mochizuki H, Nagai Y.
Blood extracellular vesicles contribute to the exercise-mediated suppression of brain Aβ pathology in the AppNL-G-F knockin mouse model of Alzheimer's disease.
Neurochem Int 106120(2026) 41548697

Ellingford R, Harris SS, Kehring M, Rajani RM, Lam FKW, Graykowski D, Bӧken D, Welikovitch LA, Khasnavis A, Laban R, Heslegrave A, Yaman U, Mate de Gerando A, Bond SA, Wray S, Salih DA, Dupret D, Dolan RJ, Klenerman D, Zetterberg H, Hyman BT, Busche MA.
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits.
Neuron (2026) 41916281

Akasaka T, Watanabe H, Ono M.
Novel BODIPY-Based Fluorescent Probes with Improved Aqueous Solubility for Selective Detection of Soluble Aβ Aggregates.
ACS Chem Neurosci (2025) 41093813

Krunic A, Bellio TA, Cohen BZ, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK.
Brain DNA Methylation Atlas of AppNL-G-F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline-Induced Resilience.
Aging Cell 24(11) e70241(2025) 41081550

Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK.
Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice.
Aging Cell e70148(2025) 41081549

Etani H, Takatori S, Wang W, Omi J, Amiya Y, Akahori A, Watanabe H, Sonn I, Okano H, Hara N, Hasegawa M, Miyashita A, Kikuchi M, Ikeuchi T, Morishima M, Saito Y, Murayama S, Saito T, Saido TC, Takai T, Ohwada T, Aoki J, Tomita T.
Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils.
Alzheimers Res Ther 17(1) 248(2025) 41261421

Yamauchi K, Koike M, Hioki H.
A three dimensional immunolabeling method with peroxidase-fused nanobodies and fluorochromized tyramide-glucose oxidase signal amplification.
Commun Biol 8(1) 903(2025) 40533487

Sunao Kawakami, Cha-Gyun Jung, Rieko Inoue, Tomohisa Nakamura, Soh Sato, Makoto Michikawa
Elevated Flotillin-1 in Saliva and Salivary Glands: A Novel Non-Invasive Biomarker in an Alzheimer’s Disease Mouse Model
Diagnostics 16 61(2025) 41515556

Huang ML, Suzuki Y, Sasaguri H, Saito T, Saido TC, Imayoshi I.
Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer's disease.
Elife 14 (2025) 41186287

Bansal VA, Tan JM, Soon HR, Zainolabidin N, Saido T, Ch'ng TH.
Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease.
Elife 13 (2025) 40132021

Guo L, Gaunt JR, Cheah CCH, Chen AI, Claudine S, Dawe GS, Goh ELK, Kho SH, Kumar P, Lim GGY, Lim KL, Lim YA, Saido TC, Saito T, Sasaguri H, Sng JCG, Yeap YJ, Yip AKK, Zainolabidin N, Ch'ng TH, Augustine GJ.
APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer's disease.
Front Neurosci 19 1629830(2025) 41211332

Gui S, Zeng F, Wu Z, Nonaka S, Sano T, Ni J, Nakanishi H, Moriyama M, Kanematsu T.
Lipopolysaccharides from Porphyromonas gingivalis indirectly induce neuronal GSK3β-dependent synaptic defects and cause cognitive decline in a low-amyloid-β-concentration environment in Alzheimer's disease.
J Alzheimers Dis 105(1) 302-316(2025) 40111934

Choi DJ, Murali S, Kwon W, Woo J, Song EC, Ko Y, Sardar D, Lozzi B, Cheng YT, Williamson MR, Huang TW, Sanchez K, Jankowsky J, Deneen B.
Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.
Nat Neurosci (2025) 41272323

Fujii K, Takeuchi T, Fujino Y, Tanaka N, Fujino N, Takeda A, Minakawa EN, Nagai Y.
Oral administration of arginine suppresses Aβ pathology in animal models of Alzheimer's disease.
Neurochem Int 191 106082(2025) 41175945

Papanikolaou A, Graykowski D, Lee BI, Yang M, Ellingford R, Zünkler J, Bond SA, Rowland JM, Rajani RM, Harris SS, Sharp DJ, Busche MA.
Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer's disease models in vivo.
Neuron (2025) 40345184

Maruyama R, Fukumori A, Funamoto S, Okada K, Akamine S, Yanagida K, Shinohara M, Sato N, Okochi M, Kudo T, Steiner H.
γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation.
Structure (2025) 41418776

Nagashima K, Watanabe H, Akasaka T, Ono M.
Development of Triphenylmethane Dyes for In Vivo Fluorescence Imaging of Aβ Oligomers.
ACS Chem Neurosci 15(11) 2233-2242(2024) 38753435

Sasaki K, Fujita H, Sato T, Kato S, Takahashi Y, Takeshita Y, Kanda T, Saito T, Saido TC, Hattori S, Hozumi Y, Yamada Y, Waki H.
GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease.
Biochem Biophys Res Commun 741 151016(2024) 39577079

Huang H, Sharoar MG, Pathoulas J, Fan L, He W, Xiang R, Yan R.
Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease.
Biochim Biophys Acta Mol Basis Dis 1870(4) 167086(2024) 38378084

Miller SR, Luxem K, Lauderdale K, Nambiar P, Honma PS, Ly KK, Bangera S, Bullock M, Shin J, Kaliss N, Qiu Y, Cai C, Shen K, Mallen KD, Yan Z, Mendiola AS, Saito T, Saido TC, Pico AR, Thomas R, Roberson ED, Akassoglou K, Bauer P, Remy S, Palop JJ.
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.
Cell Rep 43(11) 114870(2024) 39427315

Mathys H, Boix CA, Akay LA, Xia Z, Davila-Velderrain J, Ng AP, Jiang X, Abdelhady G, Galani K, Mantero J, Band N, James BT, Babu S, Galiana-Melendez F, Louderback K, Prokopenko D, Tanzi RE, Bennett DA, Tsai LH, Kellis M.
Single-cell multiregion dissection of Alzheimer's disease.
Nature 632(8026) 858-868(2024) 39048816

Abdelhamid M, Jung CG, Zhou C, Inoue R, Chen Y, Sento Y, Hida H, Michikawa M.
Potential Therapeutic Effects of Bifidobacterium breve MCC1274 on Alzheimer's Disease Pathologies in AppNL-G-F Mice.
Nutrients 16(4) (2024) 38398861

Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, Busche MA.
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
PLoS Biol 22(7) e3002727(2024) 39042667

Fukuda M, Okanishi H, Ino D, Ono K, Kawamura S, Wakai E, Miyoshi T, Sato T, Ohta Y, Saito T, Saido TC, Inohara H, Kanai Y, Hibino H.
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.
PLoS One 19(5) e0303375(2024) 38728348

Bellio TA, Laguna-Torres JY, Campion MS, Chou J, Yee S, Blusztajn JK, Mellott TJ.
Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer's disease model mice.
PLoS One 19(2) e0297289(2024) 38315685

Yamada H, Yamazaki Y, Takebayashi Y, Yazawa K, Sasanishi M, Motoda A, Nakamori M, Morino H, Takahashi T, Maruyama H.
The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease.
Sci Rep 14(1) 227(2024) 38167640

AlQot HE, Rylett RJ.
Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer's disease-like pathology in the APPNL-G-F knock-in mouse model.
Sci Rep 14(1) 27614(2024) 39528509

Takebayashi Y, Yamazaki Y, Yamada H, Yazawa K, Nakamori M, Kurashige T, Morino H, Takahashi T, Sotomaru Y, Maruyama H.
Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease.
Biochem Biophys Res Commun 683 149106(2023) 37857162

Keramidis I, McAllister BB, Bourbonnais J, Wang F, Isabel D, Rezaei E, Sansonetti R, Degagne P, Hamel JP, Nazari M, Inayat S, Dudley JC, Barbeau A, Froux L, Paquet ME, Godin AG, Mohajerani MH, De Koninck Y.
Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations.
Brain 146(12) 4903-4915(2023) 37551444

Ho H, Kejzar N, Sasaguri H, Saito T, Saido TC, De Strooper B, Bauza M, Krupic J.
A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.
Cell Rep Methods 3(7) 100532(2023) 37533650

Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T.
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.
EMBO Mol Med 15(5) e17052(2023) 36994913

Daniels MJD, Lefevre L, Szymkowiak S, Drake A, McCulloch L, Tzioras M, Barrington J, Dando OR, He X, Mohammad M, Sasaguri H, Saito T, Saido TC, Spires-Jones TL, McColl BW.
Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.
Elife 12 (2023) 38085657

Yoshida K, Kato D, Sugio S, Takeda I, Wake H.
Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer's disease.
Front Cell Neurosci 17 1154196(2023) 38026691

Kaneko R, Matsui A, Watanabe M, Harada Y, Kanamori M, Awata N, Kawazoe M, Takao T, Kobayashi Y, Kikutake C, Suyama M, Saito T, Saido TC, Ito M.
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.
Inflamm Regen 43(1) 20(2023) 36922861

Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D.
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
Int J Mol Sci 24(6) (2023) 36982771

Sahu B, Johnson LM, Sohrabi M, Usatii AA, Craig RMJ, Kaelberer JB, Chandrasekaran SP, Kaur H, Nookala S, Combs CK.
Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer's Disease in AppNL-G-F Mice.
Int J Mol Sci 24(14) (2023) 37511312

Osman B, Wang Z, Shiraishi K, Yokoyama M and Matsumura Y.
Precipitation of Insoluble Fibrin in the Brains of Alzheimer’s Disease Model Mice.
J Blood Disord 10(1) 1070(2023)

Akasaka T, Watanabe H, Ono M.
In Vivo Near-Infrared Fluorescence Imaging Selective for Soluble Amyloid β Aggregates Using y-Shaped BODIPY Derivative.
J Med Chem (2023) 37824378

Naganuma F, Murata D, Inoue M, Maehori Y, Harada R, Furumoto S, Kudo Y, Nakamura T, Okamura N.
A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer's Disease Mouse Model.
Mol Imaging Biol 25(6) 1115-1124(2023) 37580462

Honda K, Saito Y, Saito H, Toyoda M, Abe R, Saito T, Saido TC, Michikawa M, Taru H, Sobu Y, Hata S, Nakaya T, Suzuki T.
Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Neurobiol Aging 123 63-74(2023) 36638682

Kilian JG, Mejias-Ortega M, Hsu HW, Herman DA, Vidal J, Arechavala RJ, Renusch S, Dalal H, Hasen I, Ting A, Rodriguez-Ortiz CJ, Lim SL, Lin X, Vu J, Saito T, Saido TC, Kleinman MT, Kitazawa M.
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.
Toxicol Sci 193(2) 175-191(2023) 37074955

Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, Tomita T.
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
iScience 26(4) 106375(2023) 37035000

Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X.
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Acta Neuropathol 144(5) 911-938(2022) 36104602

Borcuk C, Héraud C, Herbeaux K, Diringer M, Panzer É, Scuto J, Hashimoto S, Saido TC, Saito T, Goutagny R, Battaglia D, Mathis C.
Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease.
Aging Brain 2 100042(2022) 36908877

Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J.
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease.
Aging Cell 21(3) e13565(2022) 35181976

Kamei N, Hashimoto A, Tanaka E, Murata K, Yamaguchi M, Yokoyama N, Kato M, Oki K, Saito T, Saido TC, Takeda-Morishita M.
Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model.
Drug Deliv Transl Res 12(11) 2667-2677(2022) 35015254

Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido
Recent Advances in the Modeling of Alzheimer’s Disease
Frontiers Neuroscience 16 (2022) 35431779

Abdelhamid M, Zhou C, Ohno K, Kuhara T, Taslima F, Abdullah M, Jung CG, Michikawa M.
Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse.
J Alzheimers Dis 85(4) 1555-1571(2022) 34958017

Murakami A, Hara T, Yamada-Kubota C, Kuwahara M, Ichikawa T, Minagi S.
Lack of occlusal support did not impact amyloid β deposition in APP knock-in mice.
J Prosthodont Res 66(1) 161-166(2022) 34305086

Ye Q, Gast G, Su X, Saito T, Saido TC, Holmes TC, Xu X.
Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing.
Neurobiol Dis 172 105820(2022) 35843448

Park H, Shin J, Kim Y, Saito T, Saido TC, Kim J.
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease.
Transl Neurodegener 11(1) 41(2022) 36109806

Gannon M, Wang B, Stringfellow SA, Quintin S, Mendoza I, Srikantha T, Roberts AC, Saito T, Saido TC, Roberson ED, Yacoubian TA.
14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer's Disease Mouse Models.
eNeuro 9(3) (2022) 35697511

Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, Moons L, De Groef L.
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Acta Neuropathol Commun 9(1) 6(2021) 33407903

Tomoyuki Mano, Ken Murata, Kazuhiro Kon, Chika Shimizu, Hiroaki Ono, Shoi Shi, Rikuhiro G. Yamada, Kazunari Miyamichi, Etsuo A. Susaki, Kazushige Touhara, Hiroki R. Ueda
CUBIC-Cloud provides an integrative computational framework toward community-driven whole-mouse-brain mapping
Cell Reports Methods 1 100038(2021) 35475238

Liu X, Zhou Q, Zhang JH, Wang KY, Saito T, Saido TC, Wang X, Gao X, Azuma K.
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Cells 10(11) (2021) 34831483

Sohrabi M, Pecoraro HL, Combs CK.
Gut Inflammation Induced by Dextran Sulfate Sodium Exacerbates Amyloid-β Plaque Deposition in the AppNL-G-F Mouse Model of Alzheimer's Disease.
J Alzheimers Dis 79(3) 1235-1255(2021) 33427741

Minamisawa M, Sato Y, Ishiguro E, Taniai T, Sakamoto T, Kawai G, Saito T, Saido TC.
Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model.
Life (Basel) 12(1) (2021) 35054427

Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M.
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Sci Transl Med 13(615) eabe5640(2021) 34644146

Narukawa M, Takahashi S, Saito T, Saido TC, Misaka T.
Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease.
J Alzheimers Dis 76(3) 997-1004(2020) 32568206

Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, Willem M, Haass C, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M.
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
J Nucl Med 61(12) 1825-1831(2020) 32414948