Strain Data Sheet

RBRC06318

Strain Information

Image
BRC No.RBRC06318
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameBALB/c-Cables1<tm1Utr>
Former Common nameBALB-Cables1 KO
H-2 Haplotype
ES Cell line
Background strainBALB/cAnNCrlCrlj
Appearance
Strain development筑波大学生命科学動物資源センター・杉山文博先生（2014）。BALB/c由来ES細胞を用いて作出。
Strain descriptionCables1遺伝子のnullノックアウトマウス。エクソン1をneoカセットで置換。ホモマウスは目立った異常は認められない。脳梁欠損形質を示すTASマウス (RBRC06317) との交配によるF1マウスは脳梁欠損を呈す。生存性、繁殖性は正常。
Colony maintenanceHomozygote x Homozygote [or Crossing to BALB/cAnNCrlCrlj]
ReferencesLaboratory Investigation, 94, 321-330 (2014) . 24336072

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cables1CDK5 and Abl enzyme substrate 118Cables1<tm1Utr>targeted mutation 1, Ken-ichi Yagami

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site18Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site18Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP18loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP18loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)18human phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸Mouse Cables1 genomic DNA, human phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, phage P1 loxP, yeast FRT sites
Research applicationCre/loxP system
Developmental Biology Research
FLP/frt system
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Truncated Cables1 Causes agenesis of the corpus callosum in mice.
Depositor杉山　文博（国立大学法人筑波大学）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability受注後、検査を施して提供
凍結精子を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data