Information1 | |
---|---|
Image | |
BRC No. | RBRC06239 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | C57BL/6-Siglec1<tm1(cre)Mtka> |
Former Common name | CD169-Cre, B6-Siglec1/Cre KI |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | 東京薬科大学生命科学部・田中正人先生。B6JN/1 ES細胞を用いて作出。 |
Strain description | CD169 (Siglec1) 遺伝子プロモーター制御下にimproved Cre遺伝子を挿入したマウス。CD169発現細胞特異的にCreリコンビナーゼを産生する。 |
Colony maintenance | Homozygote x Homozygote [or crossing to C57BL/6JJcl] |
References | J. Am. Soc. Nephrol., 26, 896-906 (2015). 25266072 Nat. Commun., 6:7802 (2015). 26193821 Genesis, 32(1):19-26 (2002). 11835670 |
Health Report | |
---|---|
Examination Date / Room / Rack | 2023/03/13Room:3-2Rack:C 2022/12/12Room:3-2Rack:C 2022/09/12Room:3-2Rack:C 2022/06/13Room:3-2Rack:C 2022/03/14Room:3-2Rack:C 2021/12/14Room:3-2Rack:C 2021/12/10Room:3-2Rack:C 2021/09/13Room:3-2Rack:C 2021/06/14Room:3-2Rack:C |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin2Siglec1<tm1(cre)Mtka>targeted mutation 1, Masato Tanaka Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter iCrephage P1 codon improved Cre (iCre)2iCre Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter polyoma virus polyA2 |
Information2 | |
---|---|
供与核酸 | Phage P1 improved Cre recombinase, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, polyoma virus polyA, mouse Siglec1 genomic DNA |
Research application | Cre/loxP system Immunology and Inflammation Research |
提供条件 | 条件を付加する。利用者は事前に寄託者(開発者)の提供承諾書を得る。 研究成果の公表にあたって寄託者の指定する文献を引用する。J. Am. Soc. Nephrol., 26, 896-906 (2015). 研究成果の公表にあたって謝辞の表明を必要とする。 本件リソースは寄託者/開発者を共著とする共同研究に限る。 |
Depositor | 田中 正人(東京薬科大学) |
Strain Status | ![]() ![]() ![]() |
Strain Availability | 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 生体マウスを1~3ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Camara A, Cordeiro OG, Alloush F, Sponsel J, Chypre M, Onder L, Asano K, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller CG. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 50(6) 1467-1481.e6(2019) 31201093 Camara A, Lavanant AC, Abe J, Desforges HL, Alexandre YO, Girardi E, Igamberdieva Z, Asano K, Tanaka M, Hehlgans T, Pfeffer K, Pfeffer S, Mueller SN, Stein JV, Mueller CG. CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling. Proc Natl Acad Sci U S A 119(3) (2022) 35031565 |