Strain Data Sheet

RBRC06233

Strain Information

Image
BRC No.RBRC06233
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameDS/Shi-Trpv3<Nh>/Shi
Former Common nameDS-Nh
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Shionogi & Co., Ltd. Arose in DS mouse that has been established as an inbred strain from a dd closed colony mice.
Strain descriptionNon-hair dominant spontaneous mutant mice arose in DS/Shi inbred souse strain. A G1717A point mutation has been found in the Trpv3, which results in Gly 573 being replaced with Ser. Coisogenic strain (RBRC06233), C57BL/6J (C57BL/6JShi) congenic (RBRC06234) and BALB/c (BALB/cMsShi) congenic (RBRC06235).Olmsted Syndrome
Colony maintenanceWild-type (female) x Heterozygote (male) [or Crossing to DS/Shi(RBRC03706)]
References
Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice.
M Haraguchi, M Hino, H Tanaka, M Maru
Exp. Anim., 46, 225-229 (1997). 9250484

Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis.
Ichiro Hikita, Takeshi Yoshioka, Tsuyoshi Mizoguchi, Kiyoshi Tsukahara, Kenta Tsuru, Hiroshi Nagai, Tsutomu Hirasawa, Yuji Tsuruta, Ryuji Suzuki, Masamitsu Ichihashi, Tatsuya Horikawa
J. Dermatol. Sci., 30, 142-153 (2002). 12413770

DS-Nh as an experimental model of atopic dermatitis induced by Staphylococcus aureus producing staphylococcal enterotoxin C.
T Yoshioka, I Hikita, T Matsutani, R Yoshida, M Asakawa, T Toyosaki-Maeda, T Hirasawa, R Suzuki, A Arimura, T Horikawa
Immunology. 108, 562-569 (2003). 12667219

Role of the Nh (Non-hair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice.
Akira Watanabe, Mitsuo Takeuchi, Masafumi Nagata, Kazuichi Nakamura, Hiroyuki Nakao, Hirofumi Yamashita, Susumu Makino, Minoru Harada, Tsutomu Hirasawa
Exp. Anim., 52, 419-423 (2003). 14625409

Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions.
Akira Watanabe, Mitsuo Takeuchi, Masafumi Nagata, Kazuichi Nakamura, Tsutomu Hirasawa, Hiroyuki Nakao, Susumu Makino, Minoru Harada
Exp. Anim., 52, 77-80 (2003). 12638241

Association of a mutation in TRPV3 with defective hair growth in rodents.
Makoto Asakawa, Takeshi Yoshioka, Takaji Matsutani, Ichiro Hikita, Minoru Suzuki, Itsuki Oshima, Kiyoshi Tsukahara, Akinori Arimura, Tatsuya Horikawa, Tsutomu Hirasawa, Tsuneaki Sakata
J. Invest. Dermatol., 126, 2664-2672 (2006). 16858425

Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.
T Yoshioka, I Hikita, M Asakawa, T Hirasawa, M Deguchi, T Matsutani, H Oku, T Horikawa, A Arimura
Immunology, 118, 293-301 (2006). 16827890

Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.
Takeshi Yoshioka, Kinichi Imura, Makoto Asakawa, Minoru Suzuki, Itsuki Oshima, Tsutomu Hirasawa, Tsuneaki Sakata, Tatsuya Horikawa, Akinori Arimura
J. Invest. Dermatol., 129, 714-722 (2009). 18754035

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Trpv3
MGI:2181407		transient receptor potential cation channel, subfamily V, member 311Trpv3<Nh>
MGI:2384170		non-hair
  • isolated focal non-epidermolytic palmoplantar keratoderma(MedGEN)

  • Olmsted syndrome 1(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal hair cycle anagen phase (MP:0008858)

  • abnormal hair cycle telogen phase (MP:0008860)

  • abnormal hair follicle orientation (MP:0000383)

  • abnormal hair growth (MP:0002073)

  • abnormal histamine physiology (MP:0002503)
    • more 8 phenotypes
  • abnormal keratinocyte physiology (MP:0003453)

  • dermatitis (MP:0001194)

  • increased hair follicle number (MP:0012110)

  • increased mast cell number (MP:0000324)

  • increased neuron number (MP:0008947)

  • increased susceptibility to bacterial infection (MP:0002412)

  • reduced fertility (MP:0001921)

  • skin lesions (MP:0001212)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Mouse Models for Human Disease
    Sensorineural Research
    Specific Term and Conditions1) In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 2) The RECIPIENT must inform the DEPOSITOR the research plan using the BIOLOGICAL RESOURCE and must obtain a prior written consent form the DEPOSITOR using the APPROVAL FORM specified by the DEPOSITOR. 3) The RECIPIENT shall use the BIOLOGICAL RESOURCE exclusively for the purpose of research which was written in the research plan. 4) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must inform the DEPOSITOR of the contents of such publication in advance. 5) The RECIPIENT contact and discuss with the DEPOSITOR in case of filing a patent application based on research results by using the BIOLOGICAL RESOURCES. 6) The RECIPIENT must contact and discuss with the DEPOSITOR in case of application for any commercial use.
    DepositorKiyoshi Yasui (Shionogi & Co., Ltd)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data