Strain Data Sheet

RBRC06180

Strain Information

Image
BRC No.RBRC06180
TypeWild-derived Inbred and Spontaneous Mutation
SpeciesMus musculus molossinus
Strain nameKOR1-Pitx3<-/->
Former Common nameKOR1-Pitx3
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoshibumi Mastushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain descriptionPitx3 gene mutant mice. Spontaneous mutation arose in KOR1 mouse colony derived from Japanese wild mice (Mus musculus molossinus). Homozygous mutant mice exhibit microphthalmia. KOR1 original line (RBRC06180), C57BL/6 background (semicongenic line) (RBRC06178), BALB/c background (RBRC06179).
Colony maintenanceHomozygote x Homozygote
References
Aphakia, a new mutation in the mouse.
Varnum D S, Stevens L C
J. Hered., 59(2):147-50 (1968). 4970465

Japanese wild mice: a rich resource for new disease models.
Matsushima Y
Exp. Anim., 61(1) 25-33 (2012). 22293669

Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.
Kenta Wada, Yoshibumi Matsushima, Tomoki Tada, Sayaka Hasegawa, Yo Obara, Yasuhiro Yoshizawa, Gou Takahashi, Hiroshi Hiai, Midori Shimanuki, Sari Suzuki, Junichi Saitou, Naoki Yamamoto, Masumi Ichikawa, Kei Watanabe, Yoshiaki Kikkawa
PLoS ONE 9(10): e111432 (2014). 25347445

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pitx3paired-like homeodomain transcription factor 319Pitx3
  • anterior segment dysgenesis 1(MedGEN)

  • cataract 11 multiple types(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 61(1) 25-33 (2012). PLoS ONE 9(10): e111432 (2014).
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data