Strain Information | |
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Image | |
BRC No. | RBRC06180 |
Type | Wild-derived Inbred and Spontaneous Mutation |
Species | Mus musculus molossinus |
Strain name | KOR1-Pitx3<-/-> |
Former Common name | KOR1-Pitx3 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Yoshibumi Mastushima, Saitama Cancer Center, Research Institute for Clinical Oncology. |
Strain description | Pitx3 gene mutant mice. Spontaneous mutation arose in KOR1 mouse colony derived from Japanese wild mice (Mus musculus molossinus). Homozygous mutant mice exhibit microphthalmia. KOR1 original line (RBRC06180), C57BL/6 background (semicongenic line) (RBRC06178), BALB/c background (RBRC06179). |
Colony maintenance | Homozygote x Homozygote |
References | Japanese wild mice: a rich resource for new disease models. Matsushima Y Exp. Anim., 61(1) 25-33 (2012). 22293669Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. Kenta Wada, Yoshibumi Matsushima, Tomoki Tada, Sayaka Hasegawa, Yo Obara, Yasuhiro Yoshizawa, Gou Takahashi, Hiroshi Hiai, Midori Shimanuki, Sari Suzuki, Junichi Saitou, Naoki Yamamoto, Masumi Ichikawa, Kei Watanabe, Yoshiaki Kikkawa PLoS ONE 9(10): e111432 (2014). 25347445 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Pitx3 | paired-like homeodomain transcription factor 3 | 19 | Pitx3 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Developmental Biology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 61(1) 25-33 (2012). PLoS ONE 9(10): e111432 (2014). |
Depositor | Yoshibumi Matsushima (Saitama Cancer Center) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |