Strain Data Sheet

RBRC05954

update : 2026-06-19

Strain Information
Image
BRC No.	RBRC05954
Type	Targeted Mutation and Chromosomal Aberration
Species	Mus musculus
Strain name	B6.129S7-Dp(7Herc2-Mkrn3)1Taku
Former Common name	B6-Dp(7C)
H-2 Haplotype
ES Cell line	AB2.2 [129S7/SvEvBrd-Hprt<b-m2>]
Background strain	C57BL/6JJcl
Appearance
Strain development	Developed by Toru Takumi, Osaka Bioscience Institute and Allan Bradley, The Wellcome Trust Sanger Institute in 2004. The mutant mice were backcrossed to C57BL/6J over 20 times.
Strain description	Chromosome-engineered mouse strain having a 6.3 Mb duplication of mouse chromosome 7 mirroring the human chromosome 15q11-13 duplication.
Colony maintenance	Heterozygote x Wild-type [C57BL/6JJcl]
References	Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Jin Nakatani, Kota Tamada, Fumiyuki Hatanaka, Satoko Ise, Hisashi Ohta, Kiyoshi Inoue, Shozo Tomonaga, Yasuhito Watanabe, Yeun Jun Chung, Ruby Banerjee, Kazuya Iwamoto, Tadafumi Kato, Makoto Okazawa, Kenta Yamauchi, Koichi Tanda, Keizo Takao, Tsuyoshi Miyakawa, Allan Bradley, Toru Takumi Cell, 137, 1235-1246 (2009). 19563756

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
HPRT	hypoxanthine guanine phosphoribosyl transferase (human)	7	HPRT
Herc2 MGI:103234	HECT and RLD domain containing E3 ubiquitin protein ligase 2	7	Herc2				developmental delay with autism spectrum disorder and gait instability(MedGEN) Prader-Willi syndrome(MedGEN)
Mkrn3 MGI:2181178	makorin, ring finger protein, 3	7	Mkrn3				Prader-Willi syndrome(MedGEN) precocious puberty, central, 2(MedGEN)
a MGI:87853	nonagouti	7	a			K14 promoter
loxP	phage P1 loxP	7	loxP

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	abnormal Purkinje cell innervation (MP:0003894) abnormal adrenaline level (MP:0003962) abnormal brain white matter morphology (MP:0008026) abnormal cued conditioning behavior (MP:0001454) abnormal eye blink conditioning behavior (MP:0002807) more 21 phenotypes abnormal locomotor behavior (MP:0001392) abnormal long bone morphology (MP:0003723) abnormal long-term depression (MP:0001898) abnormal noradrenaline level (MP:0003964) abnormal odor adaptation (MP:0009562) abnormal social/conspecific interaction behavior (MP:0002557) decreased circulating osteocalcin level (MP:0030985) decreased osteoblast cell number (MP:0004989) decreased osteoid thickness (MP:0010930) decreased osteoid volume (MP:0010927) decreased serotonin level (MP:0010070) decreased trabecular bone mass (MP:0010873) decreased vocalization (MP:0020351) enhanced coordination (MP:0003858) genetic imprinting (MP:0003121) increased anxiety-related response (MP:0001363) increased dopamine level (MP:0001906) increased fear-related response (MP:0003459) increased startle reflex (MP:0001488) increased susceptibility to age related obesity (MP:0003212) long stride length (MP:0010540)
Detailed phenotype data

Phenotype annotation from literatures by Mammalian phenotype ontology

abnormal Purkinje cell innervation (MP:0003894)

abnormal adrenaline level (MP:0003962)

abnormal brain white matter morphology (MP:0008026)

abnormal cued conditioning behavior (MP:0001454)

abnormal eye blink conditioning behavior (MP:0002807)

more 21 phenotypes

abnormal locomotor behavior (MP:0001392)

abnormal long bone morphology (MP:0003723)

abnormal long-term depression (MP:0001898)

abnormal noradrenaline level (MP:0003964)

abnormal odor adaptation (MP:0009562)

abnormal social/conspecific interaction behavior (MP:0002557)

decreased circulating osteocalcin level (MP:0030985)

decreased osteoblast cell number (MP:0004989)

decreased osteoid thickness (MP:0010930)

decreased osteoid volume (MP:0010927)

decreased serotonin level (MP:0010070)

decreased trabecular bone mass (MP:0010873)

decreased vocalization (MP:0020351)

enhanced coordination (MP:0003858)

genetic imprinting (MP:0003121)

increased anxiety-related response (MP:0001363)

increased dopamine level (MP:0001906)

increased fear-related response (MP:0003459)

increased startle reflex (MP:0001488)

increased susceptibility to age related obesity (MP:0003212)

long stride length (MP:0010540)

Detailed phenotype data

Ordering Information
Donor DNA	human HPRT genomic DNA, human Keratin14 genomic DNA, mouse Agouti genomic DNA, mouse Tyrosinase genomic DNA, Phage P1 loxP site
Research application	Cre/loxP system Developmental Biology Research Mouse Models for Human Disease Neurobiology Research
Specific Term and Conditions	The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Depositor	Toru Takumi (RIKEN)
Strain Status	Frozen embryos Frozen sperm
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Genotyping protocol -PCR- Mouse of the Month Apr 2015

BRC mice in Publications

No Data