Strain Data Sheet

RBRC05798

Strain Information

Image
BRC No.RBRC05798
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6.Cg-c/c Hr<hr>
Former Common nameB6-alb-Hr, B6-c/c hr
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Kazuhiko Ochiai, Department of Veterinary, Nippon Veterinary and Life Science University and Dr. Yoshihiro Miwa, Graduate School of Comprehensive Human Sciences, University of Tsukuba. Hr<hr> mutation from Hos : HR-1 was introduced into albino C57BL/6 mice by backcrossing.
Strain descriptionAlbino and hairless mutants mice of C57BL/6 genetic background.
Colony maintenanceHr: Heterozygote (female) x Homozygote (male) ; Tyr: Homozygote x Homozygote
References
The hairless mouse in skin research.
Fernando Benavides, Tatiana M Oberyszyn, Anne M VanBuskirk, Vivienne E Reeve, Donna F Kusewitt
J. Dermatol. Sci., 53, 10-18 (2009). 18938063

Health Report

Examination Date / Room / Rack2025/10/20Room:4-BRack:KSentinel mouse program
2025/08/04Room:4-BRack:KSentinel mouse program
2025/05/26Room:4-BRack:KSentinel mouse program
2025/02/25Room:4-BRack:KSentinel mouse program
2024/11/25Room:4-BRack:KSentinel mouse program
2024/08/26Room:4-BRack:KSentinel mouse program
2024/05/27Room:4-BRack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hr
MGI:96223		lysine demethylase and nuclear receptor corepressor14Hr<hr>
MGI:1856057		hairless
  • alopecia universalis congenita(DisGeNET, MedGEN)

  • atrichia with papular lesions(DisGeNET, MedGEN)
    • Tyr
    MGI:98880    		tyrosinase7Tyr<c-2J>
    MGI:1855985    		albino 2 Jackson
  • oculocutaneous albinism type 1A(DisGeNET, MedGEN)

  • oculocutaneous albinism type 1B(MedGEN)

  • oculocutaneous albinism(DisGeNET)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal aqueous drainage system morphology (MP:0005198)

  • abnormal coat appearance (MP:0001510)

  • abnormal dermis reticular layer morphology (MP:0005081)

  • abnormal eye physiology (MP:0005253)

  • abnormal hair growth (MP:0002073)
    • more 38 phenotypes
  • abnormal intraocular pressure (MP:0005257)

  • abnormal keratinocyte apoptosis (MP:0001224)

  • abnormal mammary gland morphology (MP:0000627)

  • abnormal melanosome morphology (MP:0005075)

  • abnormal nursing (MP:0001382)

  • abnormal retina ganglion layer morphology (MP:0005241)

  • abnormal retina morphology (MP:0001325)

  • abnormal retina photoreceptor morphology (MP:0001004)

  • abnormal skin condition (MP:0001191)

  • abnormal skin morphology (MP:0002060)

  • abnormal vision (MP:0002090)

  • absent coat pigmentation (MP:0005171)

  • absent hair follicle melanin granules (MP:0000394)

  • absent linear vestibular evoked potential (MP:0004813)

  • absent skin pigmentation (MP:0001189)

  • decreased T cell number (MP:0005018)

  • decreased T cell proliferation (MP:0005095)

  • decreased a-wave amplitude (MP:0012143)

  • decreased b-wave amplitude (MP:0012144)

  • decreased cell proliferation (MP:0000352)

  • decreased incidence of tumors by UV induction (MP:0004504)

  • decreased retina photoreceptor cell number (MP:0001327)

  • decreased sensitivity to skin irradiation (MP:0001204)

  • deformed nails (MP:0000580)

  • dermal cyst (MP:0001247)

  • epidermal hyperplasia (MP:0001222)

  • hairless (MP:0003815)

  • hyperkeratosis (MP:0001242)

  • increased cellular sensitivity to ionizing radiation (MP:0004227)

  • increased incidence of tumors by UV-induction (MP:0004501)

  • increased leukemia incidence (MP:0002026)

  • increased macrophage cell number (MP:0005425)

  • increased prostaglandin level (MP:0009814)

  • increased squamous cell carcinoma incidence (MP:0004207)

  • ocular albinism (MP:0006159)

  • retina degeneration (MP:0001326)

  • sebaceous gland atrophy (MP:0000649)

  • wrinkled skin (MP:0001211)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorKazuhiko Ochiai (Nippon Veterinary and Animal Science University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Rahmawati NY, Dinh TTH, Oikawa T, Shinogi A, Ikeda K, Kadota M, Tamura M, Amano T, Yoshiki A.
    Luminescent mouse model of endometriosis: three-dimensional morphology of lesions and cytokine profiles.
    Exp Anim (2025) 40350305
    Nakashiba T, Ogoh K, Iwano S, Sugiyama T, Mizuno-Iijima S, Nakashima K, Mizuno S, Sugiyama F, Yoshiki A, Miyawaki A, Abe K.
    Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging.
    Lab Anim (NY) (2023) 37679611