Strain Data Sheet

RBRC05672

Strain Information

Image
BRC No.RBRC05672
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6;Cg-Oca2<p-cas>/1Nga
Former Common nameB6-p<cas>/R, B6.Cg-Oca2<p-cas>/R, p-cas-BL
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Akira Ishikawa, Graduate School of Bioagricultural Science, Nagoya University in 2012.
Strain descriptionB6JJcl congenic strain having a pink-eyed dilution derived from Mus mucsculus castaneous mice. The strain does not show progressive darkening of the eyes and coat hair with aging.
Colony maintenanceHomozygote x Homozygote Homozygous mice are viable and fertile.
References
A new spontaneous allele at the pink-eyed dilution (p) locus discovered in Mus musculus castaneus.
Tsuji A, Wakayama T, Ishikawa A
Exp. Anim., 44, 347-351 (1995). 8575552

l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation.
Hirobe T, Ishikawa A
J. Darmatol. Sci., 80, 203-211 (2015). 26475433

Development of a novel pink-eyed dilution mouse model showing progressive darkening of the eyes and coat hair with aging.
Ishikawa A, Sugiyama M, Hondo E, Kinoshita K, Yamagishi Y
Exp. Anim., 64 (2): 207-220 (2015). 25739360

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Oca2
MGI:97454		oculocutaneous albinism II7Oca2<p-cas>
MGI:1857334		pink-eyed dilution castaneus
  • oculocutaneous albinism type 2(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal eye pigmentation(MP:0001324)

  • diluted coat color(MP:0000371)

  • yellow coat color(MP:0003136)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Sensorineural Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 64(2): 207-220 (2015).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For profit use of the BIOLOGICAL RESSOURCE, the RECIPIENT must contact with the Intellectual Property Office, Nagoya University to obtain a prior written consent.
    The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with DEPOSITOR. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for scientific research for publishing paper(s). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorAkira Ishikawa (Nagoya University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data