Strain Data Sheet

RBRC05603

Strain Information

Image
BRC No.RBRC05603
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.FVB-Tg(Col1a1-cre)1Kry
Former Common namealpha 1(I)-Cre, B6-Col1a1Cre Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Gerard Karsenty, Department of Molecular and Human Genetics, Baylor College of Medicine, Texas in 2002. The transgene was injected into the pronuclei of FVB fertilized eggs. The mice were crossed to C57BL/6J.
Strain descriptionCol1a1-cre transgenic mice. These transgenic mice express cre recombinase under the control of the mouse collagen, type I, alpha 1 promoter.
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
References
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast.
Dacquin R, Starbuck M, Schinke T, Karsenty G
Dev. Dyn., 224, 245-251(2002). 12112477

Health Report

Examination Date / Room / Rack2024/05/20Room:4-ARack:B
2024/02/19Room:4-ARack:B
2023/11/20Room:4-ARack:B
2023/08/21Room:4-ARack:B
2023/06/26Room:4-ARack:B
2023/05/22Room:4-ARack:B
2023/02/20Room:4-ARack:B
2022/11/21Room:4-ARack:B

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
crePhage P1 Cre recombinaseUNcretransgene insertion 1, Gerard Karsentymouse alpha 1(I)-collagen promoter
  • Caffey disease(MedGEN)

  • combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1(MedGEN)

  • Ehlers-Danlos syndrome, arthrochalasis type(MedGEN)
    • more 6 Diseases
  • osteogenesis imperfecta type 1(DisGeNET, MedGEN)

  • osteogenesis imperfecta type 2(DisGeNET, MedGEN)

  • osteogenesis imperfecta type 3(DisGeNET, MedGEN)

  • osteogenesis imperfecta type 4(DisGeNET, MedGEN)

  • osteogenesis imperfecta(DisGeNET)

  • osteoporosis(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse alpha 1 (I)-collagen promoter, Bacteriophage P1 Cre recombinase gene, Mouse Metallothionein MT-I polyA site
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Dyn., 224, 245-251 (2002).
    DepositorYasushi Okazaki (Saitama Medical University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Hayata T, Chiga M, Ezura Y, Asashima M, Katabuchi H, Nishinakamura R, Noda M.
    Dullard deficiency causes hemorrhage in the adult ovarian follicles.
    Genes Cells 23(5) 345-356(2018) 29521016
    Yoshioka H, Okita S, Nakano M, Minamizaki T, Nubukiyo A, Sotomaru Y, Bonnelye E, Kozai K, Tanimoto K, Aubin JE, Yoshiko Y.
    Single-Cell RNA-Sequencing Reveals the Breadth of Osteoblast Heterogeneity.
    JBMR Plus 5(6) e10496(2021) 34189385