Strain Data Sheet

RBRC05557

Strain Information

Image
BRC No.RBRC05557
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6J.MSM-Asmt<MSM>
Former Common nameB6- Hiomt<MSM>, B6J.MSM-Hiomt<MSM>
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Takaoki Kasahara, RIKEN Brain Science Institute and Shigeharu Wakana, RIKEN BioResource Center in 2011. This congenic strain was generated by backcrossing to C57BL/6J from MSM/Ms.
Strain descriptionC57BL/6J congenic strain having Hiomt gene derived from Japanese wild-derived inbred mice, MSM/Ms. Melatonin synthesis requires enzymes encoded by Aanat and Hiomt genes. B6J.MSM-Aanat<MSM> Hiomt<MSM> (RBRC05503), B6J.MSM-Aanat<MSM> (RBRC05556), B6J.MSM-Hiomt<MSM> (RBRC05557).
Colony maintenanceHomozygote x Homozygote
References
Genetic variation of melatonin productivity in laboratory mice under domestication.
Takaoki Kasahara, Kuniya Abe, Kazuyuki Mekada, Atsushi Yoshiki, Tadafumi Kato
Proc. Natl. Acad. Sci. USA, 107, 6412-6417 (2010). 20308563

Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice.
Chongyang Zhang, Shannon J Clough, Ekue B Adamah-Biassi, Michele H Sveinsson, Anthony J Hutchinson, Ikuo Miura, Tamio Furuse, Shigeharu Wakana, Yui K Matsumoto, Kazuo Okanoya, Randall L Hudson, Tadafumi Kato, Margarita L Dubocovich, Takaoki Kasahara
J. Pineal. Res., 71(2):e12748 (2021). 34085306

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Asmt
MGI:96090		acetylserotonin O-methyltransferaseXAsmt<MSM/Ms> MSM/Ms

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal pineal gland melatonin secretion (MP:0011729)

  • abnormal pineal gland physiology (MP:0011728)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Pineal. Res., 71(2):e12748 (2021). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Takaoki Kasahara) using the Approval Form.
    DepositorTadafumi Kato (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data