Strain Data Sheet

RBRC05119

Strain Information

Image
BRC No.RBRC05119
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC;B6CB-Tnf<tm1Sek>
Former Common nameBALB-Tnf KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development1997年 家畜衛生試験場 関川賢二先生らにより開発。TT2 ES細胞由来。東大医科研岩倉研でBALB/cAに8世代戻し交配 (兄妹交配7代) (BRC寄託時)。(C57BL/6 × CBA) F1 (TT2)
Strain descriptionTNF alpha遺伝子欠損マウス。細菌等に対して易感染性。
Colony maintenanceBALB/cAJcl
References
Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice.
Taniguchi T, Takata M, Ikeda A, Momotani E, Sekikawa K
Lab. Invest., 77, 647-658 (1997). 9426403

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnf
MGI:104798		tumor necrosis factor17Tnf<tm1Sek> targeted mutation 1, Kenji Sekikawa
  • inherited susceptibility to asthma(MedGEN)

  • malaria, susceptibility to(MedGEN)

  • migraine with or without aura, susceptibility to, 1(MedGEN)
    • neo neomycin resistance gene (E. coli)17 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Peyer's patch germinal center morphology(MP:0002391)

  • abnormal cytokine secretion(MP:0003009)

  • abnormal female reproductive system physiology(MP:0003699)

  • abnormal liver physiology(MP:0000609)

  • abnormal macrophage physiology(MP:0002451)
    • more 18 phenotypes
  • abnormal mesenteric lymph node morphology(MP:0005232)

  • abnormal serotonin level(MP:0005322)

  • abnormal vagina weight(MP:0008978)

  • absent lymph node germinal center(MP:0008523)

  • absent spleen germinal center(MP:0008474)

  • decreased circulating interferon-gamma level(MP:0008578)

  • decreased circulating interleukin-1 alpha level(MP:0008639)

  • decreased circulating interleukin-1 beta level(MP:0008642)

  • decreased circulating interleukin-6 level(MP:0008597)

  • decreased coping response(MP:0003064)

  • decreased locomotor activity(MP:0001402)

  • decreased susceptibility to endotoxin shock(MP:0008734)

  • decreased vertical activity(MP:0002757)

  • immune system phenotype(MP:0005387)

  • increased anxiety-related response(MP:0001363)

  • increased grooming behavior(MP:0001441)

  • increased serotonin level(MP:0010069)

  • prolonged estrus(MP:0009017)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse tnf genomic DNA, Neomycin resistance gene (E. coli), Phosphoglycerate kinase (PGK) promoter (mouse)
    Research applicationImmunology and Inflammation Research
    covid19_onset
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Lab. Invest., 77, 647-658 (1997). 研究成果の公表にあたって謝辞の表明を必要とする。研究成果の公表にあたって寄託者の指定する文献を引用する。
    Depositor岩倉　洋一郎（国立大学法人東京大学）
    Strain Status凍結精子のアイコン凍結精子
    Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data