Strain Information | |
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Image | |
BRC No. | RBRC05118 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;B6CB-Tnf<tm1Sek> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Kenji Sekikawa, STAFF-Institute in 1997. The mice were backcrossed to C57BL/6 for at least 12 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. |
Strain description | TNF alpha knockout mice. Homozygous mutant mice show increased susceptibility to infection. |
Colony maintenance | |
References | Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Taniguchi T, Takata M, Ikeda A, Momotani E, Sekikawa K Lab. Invest., 77, 647-658 (1997). 9426403 |
Health Report | |
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Examination Date / Room / Rack | 2024/08/26Room:4-BRack:J 2024/05/27Room:4-BRack:J 2024/02/26Room:4-BRack:J 2023/11/27Room:4-BRack:J 2023/08/28Room:4-BRack:J 2023/05/29Room:4-BRack:J 2023/02/27Room:4-BRack:J 2022/11/29Room:4-BRack:J |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Tnf | tumor necrosis factor | 17 | Tnf | targeted mutation 1, Kenji Sekikawa | |||
neo | neomycin resistance gene (E. coli) | 17 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 18 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Tnf genomic DNA |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Lab. Invest., 77, 647-658 (1997). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Yoichiro Iwakura (The University of Tokyo) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |