Strain Data Sheet

RBRC05065

Strain Information

Image
BRC No.RBRC05065
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.B6CB-Sox1<tm1(cre)Take>
Former Common nameB6-Sox1/cre KI
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentCre recombinase was inserted into the ATG codon start site if Sox1 by in-frame. PGK-neo cassette was removed by Flp recombinase expression.
Strain descriptionSox1 cre knock-in mice. knocked into the Sox1 gene. No obvious defect at the heterozygous state which is used for the conditional KO or cell tracing purposes.
Colony maintenanceHeterozygote X Wild-type [C57BL/6NJcl]
ReferencesCell, 129, 1377-1388 (2007). 17604725

Health Report

Examination Date / Room / Rack2024/01/22Room:3-CRack:B
2023/10/23Room:3-CRack:B
2023/07/24Room:3-CRack:B
2023/05/22Room:3-CRack:B
2023/04/24Room:3-CRack:B
2023/01/23Room:3-CRack:B
2022/10/25Room:3-CRack:B
2022/07/25Room:3-CRack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Sox1SRY-box containing gene 18Sox1<tm1(cre)Take>targeted mutation 1, Takumi Era

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site8Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinase8cre

Ordering Information

供与核酸Phage P1 cre recombinase, yeast FRT (flippase recombination target) site, mouse Sox1 genomic DNA
Research applicationCre/loxP system
FLP/frt system
提供条件条件を付加する。
(1) 当該マウスを用いる論文発表に際しては Accession No. CDB0525K、その WEB サイト（https://large.riken.jp/distribution/mutant-list.htmlとともに当該マウスを記載すること。(2) 当該マウスを用いる論文発表に際しては、その由来として第一報論文（Cell, 129, 1377-1388 (2007).）を引用すること。
DepositorRIKEN CDB（独立行政法人理化学研究所）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを3~6ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H.
UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.
FASEB J 36(12) e22662(2022) 36412518

Sakai D, Sugawara T, Kurokawa T, Murakami Y, Tomosugi M, Masuta H, Sakata-Haga H, Hatta T, Shoji H.
Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model.
Mol Brain 15(1) 28(2022) 35361248