Strain Information | |
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Image | |
BRC No. | RBRC04918 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129S2-Il6<tm1Kopf> |
Former Common name | B6.129S2-Il6<tm1Kopf> |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1994. The mice were backcrossed to C57BL/6 for at least 8 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. |
Strain description | IL-6 knockout mice. Homozygous mutant mice show decreased immune competence. slight overweight with aging. |
Colony maintenance | |
References | Nature, 368, 339-342 (1994). 8127368 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)5neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA5 |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il6 genomic DNA |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 368, 339-342 (1994).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Yoichiro Iwakura (The University of Tokyo) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |