Strain Data Sheet

RBRC04863

Strain Information

Image
BRC No.RBRC04863
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB10.HR-Oca2<p>/Hir
Former Common nameB10-p
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tomohisa Hirobe, National Institute of Radiological Sciences in 1986. Pink-eyed dilution (p) locus from HR/De (Aichi Cancer Center) was backcrossed into the C57BL/10JMsHir, and then mantained by sister-brother mating.
Strain descriptionC57BL/10 congenic strain of pink-eyed dilution locus from HR strain. Pink-eyed dilution (a/a B/B C/C D/D p/p E/E). Reduction of melanin in melanocytes.
Colony maintenanceHomozygote x Homozygote
References
Control of melanocyte proliferation and differentiation in the mouse epidermis.
T Hirobe
Pigment Cell Res., 5, 1-11 (1992). 1631016

Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture.
T Hirobe, H Abe
Pigment Cell Res., 12, 147-163 (1992). 10385911

Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.
T Hirobe
Histol Histopathol., 10, 223-237 (1995). 7756740

Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes.
Tomohisa Hirobe
Pigment Cell Res., 18, 2-12 (2005). 15649147

How are proliferation and differentiation of melanocytes regulated?
Tomohisa Hirobe
Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Oca2
MGI:97454		oculocutaneous albinism II7Oca2<p>
MGI:1856114		pink-eyed dilution
  • oculocutaneous albinism type 2(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal coat/hair pigmentation (MP:0002075)

  • abnormal eye pigmentation (MP:0001324)

  • absent eye pigmentation (MP:0008480)

  • cleft palate (MP:0000111)

  • darkened coat color (MP:0005409)
    • more 3 phenotypes
  • decreased eye pigmentation (MP:0005172)

  • decreased tail pigmentation (MP:0011277)

  • diluted coat color (MP:0000371)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationSensorineural Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Pigmnet Cell Melanoma Res., 24(3):462-478 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTomohisa Hirobe (National Institute of Radiological Sciences (NIRS))
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data