Strain Information | |
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Image | |
BRC No. | RBRC04863 |
Type | Spontaneous Mutation Congenic |
Species | Mus musculus |
Strain name | B10.HR-Oca2<p>/Hir |
Former Common name | B10-p |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Tomohisa Hirobe, National Institute of Radiological Sciences in 1986. Pink-eyed dilution (p) locus from HR/De (Aichi Cancer Center) was backcrossed into the C57BL/10JMsHir, and then mantained by sister-brother mating. |
Strain description | C57BL/10 congenic strain of pink-eyed dilution locus from HR strain. Pink-eyed dilution (a/a B/B C/C D/D p/p E/E). Reduction of melanin in melanocytes. |
Colony maintenance | Homozygote x Homozygote |
References | Control of melanocyte proliferation and differentiation in the mouse epidermis. Hirobe T Pigment Cell Res., 5, 1-11 (1992). 1631016Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture. Hirobe T, Abe H Pigment Cell Res., 12, 147-163 (1992). 10385911Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Hirobe T Pigment Cell Res., 18, 2-12 (2005). 15649147Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle. Hirobe T Histol Histopathol., 10, 223-237 (1995). 7756740How are proliferation and differentiation of melanocytes regulated? Hirobe T Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Oca2 | oculocutaneous albinism II | 7 | Oca2 | pink-eyed dilution |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 3 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Sensorineural Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Pigmnet Cell Melanoma Res., 24(3):462-478 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Tomohisa Hirobe (National Institute of Radiological Sciences (NIRS)) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |