Strain Data Sheet

RBRC04851

Strain Information

Image
BRC No.RBRC04851
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6C3(129)-Tg(NDE-hsp-Alk4DN,lacZ)1Hmd
Former Common nameNDE-dnAlk4-1Z(1)
H-2 Haplotype
ES Cell line
Background strainJcl:B6C3F1
Appearance
Strain developmentDeveloped by Aiko Kawasumi and Hiroshi Hamada, Graduate School of Frontier Biosciences, Osaka University in 2010 The transgene was injected into the pronuclei of (C57BL/6 x C3H) F1 fertelized eggs. C57BL/6, C3H and 129 mixed background.
Strain description
Colony maintenanceCarrier x Noncarrier [or Crossing to Jcl:B6C3F1]
References
Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.
Kawasumi A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Belo J A, Shiratori H, Hamada H
Dev. Biol., 353, 321-330 (2011). 21419113

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Acvr1b
MGI:1338944		activin A receptor, type 1BUNAcvr1b
IRES internal ribosomal entry site (EMCV)UN
lacZ beta-galactosidase (E. coli)UN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAマウス由来NodalのNDEエンハンサー dominant negative (KR) 型に改変したAlk4 cDNA, hspプロモーター, E. coli由来LacZ遺伝子, ウィルス由来IRES配列
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 353, 321-330 (2011).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data