Strain Data Sheet

RBRC04846

Strain Information

Image
BRC No.RBRC04846
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CAG-St6gal1)3
Former Common nameB6-St6gal1 Tg#3
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yasuhiro Hashimoto, Fukushima Medical University in 2006.
Strain description
Colony maintenanceCarrier x Noncarrier [C57BL/6]
References
Immune regulation by the ST6Gal sialyltransferase.
Hennet T, Chui D, Paulson J C, Marth J D
Proc. Natl. Acad. Sci. USA, 95, 4504-4509 (1998). 9539767

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Kitazume S, Tachida Y, Oka R, Shirotani K, Saido T C, Hashimoto Y
Proc. Natl. Acad. Sci. USA, 98, 13554-13559 (2001). 11698669

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FLAGFLAG tag (synthetic)UNFLAG
St6gal1beta galactoside alpha 2,6 sialyltransferase 1 (rat)UNSt6gal1CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased total body fat amount(MP:0010025)
  • Detailed phenotype data

    Ordering Information

    Donor DNArat ST6GalI, synthetic FLAG epitope tag sequence, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
    Research applicationCancer Research
    Immunology and Inflammation Research
    Virology Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE. For period of two (2) years after deposition by the DEPOSITOR to the REKEN BRC, the RESIPIENT agrees to include the DEPOSITOR/DEVELOPER (Yashuhiro Hashimoto, Shinobu Kitazume, Satoshi Futakawa) as a co-authors.
    DepositorYasuhiro Hashimoto (Fukushima Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data