Strain Data Sheet

RBRC04834

Strain Information

Image
BRC No.RBRC04834
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameC57BL/6J-Slc7a11<m1Mtka>
Former Common namexCT mutant
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.
Strain descriptionSlc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Colony maintenanceHeterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
References
xCT deficiency accelerates chemically induced tumorigenesis.
Ami Nabeyama, Ai Kurita, Kenichi Asano, Yasunobu Miyake, Takuwa Yasuda, Ikuo Miura, Gen Nishitai, Satoko Arakawa, Shigeomi Shimizu, Shigeharu Wakana, Hisahiro Yoshida, Masato Tanaka
Proc. Natl. Acad. Sci. USA, 107, 6436-6441 (2010). 20308543

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Slc7a11
MGI:1347355		solute carrier family 7 (cationic amino acid transporter, y+ system), member 113Slc7a11<m1Mtka>
MGI:4442905		mutation 1, Masato Tanaka

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal dendritic cell physiology (MP:0002376)

  • abnormal macrophage physiology (MP:0002451)

  • decreased cell proliferation (MP:0000352)

  • decreased fibroblast proliferation (MP:0011704)

  • immune system phenotype (MP:0005387)
    • more 1 phenotypes
  • increased incidence of tumors by chemical induction (MP:0004499)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Immunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorMasato Tanaka (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data