Strain Data Sheet
RBRC04664
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC04664 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | 129;FVB-Tg(PDGFB-Ptn)2Rau |
| Former Common name | |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Dveloped by Dr. Heikki Rauvala, Institute of Biotechnology and Department of Biosciences, University of Helsinki. PDGF-beta promoter followed by rabbit beta-globulin intron and HB-GAM cDNA and sv40 poly-A-tail. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342. |
| Strain description | Transgenic mice overexpressing HB-GAM (pleiotrophin). Attenuated long-term potentiation (LTP) in hippocampus. Faster learning in water maze and decreased anxiety in elevated plus-maze compared to the wild-type mice. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342. Tg mice are viable and no anatomical abnormalities are detected. |
| Colony maintenance | Carrier x Carrier |
| References | Mol. Cell. Neurosci., 20, 330-342 (2002). 12093164 |
Health Report | |
|---|---|
| Examination Date / Room / Rack | |
Gene | |
|---|---|
| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
|---|---|
| 供与核酸 | Human PDGF-beta promoter, Rabiit beta-globin intron, Rat HB-GAM (pleitroghin) cDNA, SV40 polyadenylation signal |
| Research application | |
| 提供条件 | 条件を付加する。 In publishing the research results obtained by use the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Mol. Cell Neurosci., 2002 20(2):330-242. A recipient shall acquire a prior consent from the DEPOSITOR for the use of the mice. |
| Depositor | Heikki Rauvala（University of Helsinki） |
| Strain Status |  凍結胚 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
|---|
| No Data |