Strain Data Sheet

RBRC04547

Strain Information

Image
BRC No.RBRC04547
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Ticam1<tm2Tsse>
Former Common nameTICAM-1 (Trif) KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped by Tsukasa Seya, Graduate School of Medicine, Hokkaido University in 2007.
Strain description
Colony maintenance
References
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T
Nat. Immunol., 4, 161-167 (2003). 12539043

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ticam1
MGI:2147032		TIR domain containing adaptor molecule 117Ticam1<tm2Tsse>
MGI:6474240		targeted mutation 2, Tsukasa Seya
  • herpes simplex encephalitis, susceptibility to, 4(MedGEN)
    • neo neomycin resistance gene (E. coli)17 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • impaired natural killer cell mediated cytotoxicity (MP:0005070)

  • increased tumor growth/size (MP:0003721)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, mouse Ticam1 genomic DNA
    Research applicationImmunology and Inflammation Research
    Virology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 4, 161-167 (2003).
    DepositorTsukasa Seya (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data