Strain Data Sheet

RBRC04546

Strain Information

Image
BRC No.RBRC04546
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129B6-Mavs<tm1Tsse>
Former Common nameIPS-1 (MAVS/VISA/Cardif) KO
H-2 Haplotype
ES Cell lineEGR-G01 [129S2 x C57BL/6NCr-Tg(CAG/Acr-EGFP)]
Background strain
Appearance
Strain development開発者 / 機関 : 押海裕之先生 / 北海道大学開発年 : 2009年C57BL/6
Strain descriptionIPS-1遺伝子をノックアウトしたC57BL/6系統マウス。細胞質内のウイルスRNAを認識するRIG-IやMDA5のアダプター分子としてIPS-1は働き、ウイルス感染時のI型インターフェロン産生に関与する。
Colony maintenance兄妹交配
References
The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T
J. Immunol., 187 (10) 5320-7 (2011). 21998457

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mavs
MGI:2444773		mitochondrial antiviral signaling protein2Mavs<tm1Tsse> targeted mutation 1, Tsukasa Seya
neo neomycin resistance gene (E. coli)2 mouse Phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse Phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistance gene, mouse mavs genomic DNA
    Research applicationImmunology and Inflammation Research
    covid19_onset
    提供条件利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
    Depositor瀬谷　司（国立大学法人北海道大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C.
    Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
    PLoS Pathog 17(10) e1009841(2021) 34648591