Strain Information | |
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Image | |
BRC No. | RBRC04546 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129B6-Mavs<tm1Tsse> |
Former Common name | IPS-1 (MAVS/VISA/Cardif) KO |
H-2 Haplotype | |
ES Cell line | EGR-G01 [129S2 x C57BL/6NCr-Tg(CAG/Acr-EGFP)] |
Background strain | |
Appearance | |
Strain development | Developed by Hiroyuki Oshiumi, Graduate School of Medicine, Hokkaido University in 2009. |
Strain description | |
Colony maintenance | |
References | The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T J. Immunol., 187 (10) 5320-7 (2011). 21998457 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Mavs | mitochondrial antiviral signaling protein | 2 | Mavs | targeted mutation 1, Tsukasa Seya | |||
neo | neomycin resistance gene (E. coli) | 2 | mouse Phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse Phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistance gene, mouse mavs genomic DNA |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Tsukasa Seya (Hokkaido University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C. Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. PLoS Pathog 17(10) e1009841(2021) 34648591 |