Strain Data Sheet

RBRC04326

Strain Information

Image
BRC No.RBRC04326
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129(D2)-Atf5<tm1.1Yuta>
Former Common nameATF5KO
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strainC57BL/6
Appearance
Strain developmentDeveloped by Yuji Tkakahashi, Tokyo University of Pharmacy and Life Science in 2010.
Strain description
Colony maintenance
References
Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron.
Umemura M, Tsunematsu K, Shimizu Y I, Nakano H, Takahashi S, Higashiura Y, Okabe M, Takahashi Y
Biosci Biotechnol Biochem. 2015;79(7):1082-1089 (2015). 25704077

Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons.
Nakano H, Iida Y, Suzuki M, Aoki M, Umemura M, Takahashi S, Takahashi Y
Cell Tissue Res., 363(3):621-33 (2016). 26395637

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atf5
MGI:2141857		activating transcription factor 57Atf5<tm1.1Yuta> targeted mutation 1.1, Yuji Takahashi
loxP phage P1 loxP7loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal GABAergic neuron physiology(MP:0011987)

  • abnormal innervation(MP:0002184)

  • abnormal olfactory bulb glomerular layer morphology(MP:0009948)

  • abnormal olfactory bulb interneuron morphology(MP:0009941)

  • abnormal olfactory bulb mitral cell layer morphology(MP:0009951)
    • more 11 phenotypes
  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal olfactory epithelium morphology(MP:0008789)

  • abnormal olfactory nerve morphology(MP:0005236)

  • abnormal olfactory sensory neuron morphology(MP:0006092)

  • absent gastric milk in neonates(MP:0009546)

  • axonal dystrophy(MP:0003225)

  • decreased aggression towards male mice(MP:0003862)

  • decreased neuronal stem cell self-renewal(MP:0012207)

  • decreased tyrosine 3-monooxygenase activity(MP:0020077)

  • neonatal lethality, incomplete penetrance(MP:0011088)

  • small olfactory bulb(MP:0002741)
    • Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage P1 loxP site, mouse Atf5 genomic DNA
    Research applicationApoptosis Research
    Cancer Research
    Cell Biology Research
    Cre/loxP system
    Developmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Tissue Res. 2015 Sep 22. [Epub ahead of print]. Biosci Biotechnol Biochem. 2015;79(7):1082-1089 (2015)In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval form the DEPOSITOR using the Approval Form. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT aiming for a not-for-profit research on the premise of publication. The RECIPIENT must submit MTA to the DEPOSITOR. In publication of the first paper describing results obtained by using the BIOGICAL RESOURCE of Depositor, the RECIPIENT must write the articles with DEPOSITOR as a coauthor.
    DepositorYuji Takahashi (Tokyo University of Pharmacy and Life Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data