Strain Information | |
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Image | |
BRC No. | RBRC04020 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Dnase2a<tm2.1Osa> |
Former Common name | DNaseII conditional knock out |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | C57BL/6 |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, Yoshikawa H, Nagata S Nature, 443, 998-1002 (2006). 17066036 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Dnase2a | deoxyribonuclease II alpha | 8 | Dnase2a | targeted mutation 2.1, Shigekazu Nagata | |||
loxP | phage P1 loxP | 8 | loxP | ||||
loxP | phage P1 loxP | 8 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse Dnase2a genomic DNA [update May 20, 2015] |
Research application | Cre/loxP system |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 443, 998-1002 (2006). RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose. The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Shigekazu Nagata (Osaka University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Aug 2012 |
BRC mice in Publications |
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Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K. DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Nat Commun 6 5853(2015) 25600358 |