Strain Information | |
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Image | |
BRC No. | RBRC03514 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Hgs<tm>/Rbrc |
Former Common name | Hrs(loxP)(Acc.No. CDB0476K) |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Kazuo Sugamura, Tohoku University Graduate School of Medicine in 2008. Deposited by Laboratory for Animal Resrouces and Genetic Engineering, RIKEN Center for Developmental Biology. |
Strain description | Hrs (Hgs, HGF-regulated tryosine kinase substrate) floxed mice. Conditional Hrs deficient mice can be generated by crossing with tissue-specific Cre mice. |
Colony maintenance | |
References | Am. J. Pathol., 173, 1806-1817 (2008). 19008375 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site11Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site11Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP11loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP11loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo, Phage P1 loxP sites, yeast FRT (flipase recombination target) sites, mouse Hgs genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from Nobuyuki Tanaka (tanaka@med.tohoku.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0476K) (https://large.riken.jp/distribution/mutant-list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Am J Pathol. 2008 173(6):1806-17.) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
Depositor | RIKEN CDB (RIKEN CDB) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |