Strain Data Sheet

RBRC03510

Strain Information

Image
BRC No.RBRC03510
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Fabp4-Foxo1*d256)/Rbrc
Former Common nameFoxO1(aP2-FLAG-Δ256 ) (Acc.No. CDB0450T)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure.
Nakae J, Cao Y, Oki M, Orba Y, Sawa H, Kiyonari H, Iskandar K, Suga K, Lombes M, Hayashi Y
Diabetes, 57, 563-576 (2008). 18162510

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxo1 forkhead box O1UNFoxo1 mouse aP2 promoter
GH Growth hormone polyA (human)UNGH

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal carbohydrate metabolism(MP:0013243)

  • abnormal mitochondrial physiology(MP:0006036)

  • decreased circulating triglyceride level(MP:0002644)

  • increased brown fat cell number(MP:0009127)

  • increased energy expenditure(MP:0004889)
    • more 2 phenotypes
  • increased oxygen consumption(MP:0005289)

  • increased triglyceride level(MP:0005317)
    • Detailed phenotype data

    Ordering Information

    Donor DNAaP2promoter(mouse), mutant Foxo1 cDNA(mouse), GH polyA signal(human)
    Research application
    Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Masato Kasuga (kasuga@ri.imcj.go.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0450T) (https://large.riken.jp/distribution/mutant-list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Diabetes. 2008 57(3):563-76.) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data